Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis - PubMed (original) (raw)

Review

. 2022 Feb;200(2):516-525.

doi: 10.1007/s12011-021-02693-3. Epub 2021 Mar 30.

Affiliations

Review

Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis

Fengyi Zhao et al. Biol Trace Elem Res. 2022 Feb.

Abstract

In recent years, the prevalence and incidence of diabetes mellitus (DM) have increased sharply worldwide. In order to evaluate the effect of chromium supplementation on patients with type 2 diabetes, a meta-analysis was conducted by searching the relevant literature. Randomized controlled trials on the effects of chromium supplements on glucose metabolism or lipid profile in patients with type 2 diabetes were retrieved from multiple databases. Literature screening, quality evaluation, and data extraction were conducted according to the inclusion and exclusion criteria, and Review Manager 5.4.0 was used for data analysis. A total of 10 randomized controlled trials involving 509 patients were included, including 269 cases in the experimental group and 240 cases in the placebo control group. Statistical analysis was conducted on the glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) to evaluate the blood glucose and lipid levels. Meta-analysis results showed that the differences between the experimental group and the control group in only one indicator of HbA1c were statistically significant, while there were no statistically significant differences in other indicators. The use of chromium supplements can reduce the glycosylated hemoglobin of type 2 diabetic patients to a certain extent, but it cannot effectively improve the fasting blood glucose and blood lipid levels of type 2 diabetic patients.

Keywords: Chromium; Diabetes mellitus; Glycated hemoglobin; Lipid profile; Triglyceride.

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Balakumar P, Maung-U K, Jagadeesh G (2016) Prevalence and prevention of cardiovascular disease and diabetes mellitus. Pharmacol Res 113(Pt A):600–609. https://doi.org/10.1016/j.phrs.2016.09.040 - DOI - PubMed
    1. International Diabetes Federation (2019) IDF diabetes atlas, 9th edn. International Diabetes Federation, Brussels, Belgium
    1. The Lancet (2017) Diabetes: a dynamic disease. Lancet (Lond Engl) 389(10085):2163. https://doi.org/10.1016/S0140-6736(17)31537-4 - DOI
    1. Cefalu WT, Hu FB (2004) Role of chromium in human health and in diabetes. Diabetes Care 27(11):2741–2751. https://doi.org/10.2337/diacare.27.11.2741 - DOI - PubMed
    1. Khodavirdipour A, Haddadi F, Keshavarzi S (2020) Chromium supplementation; negotiation with diabetes mellitus, hyperlipidemia, and depression. J Diabetes Metab Disord 19(1):585–595. https://doi.org/10.1007/s40200-020-00501-8 - DOI - PubMed - PMC

Publication types

MeSH terms

Substances

LinkOut - more resources