Assessment of the association between body composition and risk of non-alcoholic fatty liver - PubMed (original) (raw)

Assessment of the association between body composition and risk of non-alcoholic fatty liver

Mohammad Ariya et al. PLoS One. 2021.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is defined as the condition of fat accumulation in the liver. This cross-sectional study aimed to investigate the relationship between body composition and fatty liver and determine of cut-off point for predicting NAFLD. Samples were selected from the nutrition clinic from 2016 to 2017 in Tehran, Iran. The liver steatosis was calculated using the CAP score through the FiroScan™ and body composition was measured using the dual-energy X-ray absorptiometry scan method. A total of 2160 patients participated in this study, 745 (34.5%) subjects had NAFLD. We found that fat-free tissue was inversely and fat tissue was directly correlated with the risk of NAFLD in almost all factors and the risk of developing NAFLD increases if the total fat exceeds 32.23% and 26.73% in women and men and abdominal fat exceeds 21.42% and 13.76% in women and men, respectively. Finally, we realized that the total fat percent had the highest AUC (0.932 for men and 0.917 for women) to predict the risk of NAFLD. Overall, the likelihood of NAFLD development rose significantly with increasing the amount of total fat and abdominal fat from the cut-off point level.

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Conflict of interest statement

The authors hereby affirm that the manuscript is original, that all statements asserted as facts are based on authors’ careful investigation and accuracy, that the manuscript has not been published in total or in part previously and has not been submitted or considered for publication in total or in part elsewhere. Each author acknowledges he/she has participated in the work substantively and is prepared to take public responsibility for the work and authors have no competing interest in the results of the article.

Figures

Fig 1

Fig 1. ROC curves for NAFLD using body fat percent.

(a) ROC for Total Fat in Males (b) ROC for Abdominal Fat in Males, (c) ROC for Total Fat in Females (d) ROC for Abdominal Fat in Females.

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