tpr homologues activate met and raf - PubMed (original) (raw)
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- PMID: 3387099
Comparative Study
tpr homologues activate met and raf
H W King et al. Oncogene. 1988 Jun.
Abstract
We have previously described the primary structure of the entire met domain and part of the tpr domain present in the human tpr-met oncogene. The isolation and sequencing of an additional cDNA clone now enables us to present the complete primary sequence of the tpr domain. A computer search has unearthed a remarkable identity between tpr and a rat sequence found at the 5-prime end of the activated raf oncogene. The occurrence of tpr-like sequences in combination with two oncogenes suggests that tpr contributes a domain(s) relevant to the observed activation of met and raf.
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