Wolfberry (Lycium barbarum) Consumption with a Healthy Dietary Pattern Lowers Oxidative Stress in Middle-Aged and Older Adults: A Randomized Controlled Trial - PubMed (original) (raw)

Wolfberry (Lycium barbarum) Consumption with a Healthy Dietary Pattern Lowers Oxidative Stress in Middle-Aged and Older Adults: A Randomized Controlled Trial

Darel Wee Kiat Toh et al. Antioxidants (Basel). 2021.

Abstract

Incorporating zeaxanthin-rich wolfberry (Lycium barbarum) into a healthy dietary pattern may augment its antioxidant potential. The present 16-week, parallel design randomized controlled trial aimed to investigate the impact of adhering to a healthy dietary pattern, either with or without whole dried wolfberry (15 g/d) on oxidative stress status (plasma malondialdehyde and 8-iso-prostaglandin F2α) in middle-aged and older adults. Changes to carotenoids status (plasma and skin carotenoids) and body composition were further evaluated to explore potential mechanisms which underlie the antioxidant properties of wolfberry. Plasma 8-iso-prostaglandin F2α, plasma zeaxanthin and skin carotenoids status were significantly raised in the wolfberry consuming group (n = 22; p < 0.05) compared to the control group which showed no changes (n = 18). Likewise in the wolfberry group only, inverse association was observed between the change values of plasma zeaxanthin and plasma 8-iso-prostaglandin F2α (-0.21 (-0.43, 0.00) ng/µmol, regression coefficient (95% CI); p = 0.05). Wolfberry consumption with a healthy dietary pattern may serve as a dietary strategy to attenuate lipid peroxidation among middle-aged and older adults who are at a heightened risk of oxidative stress induced age-related disorders. The antioxidant properties of wolfberry may be attributed to its rich zeaxanthin content.

Keywords: Lycium barbarum; antioxidant; body composition; middle-aged; oxidative stress; plasma carotenoids; randomized controlled trial; skin carotenoids.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure A1

Figure A1

Representative chromatogram for plasma carotenoids analysis.

Figure 1

Figure 1

Consolidated Standards of Reporting Trials (CONSORT) flow diagram for randomized controlled trial 2. 1 Dietary assessment was absent for one participant from each group at week 0. 2 The wolfberry group received dietary counselling to adhere to a healthy dietary pattern and consumed 15 g/d whole while the control group received dietary counselling to adhere to a healthy dietary pattern only.

Figure 2

Figure 2

Concentrations of plasma oxidative stress biomarkers MDA and 8-isoPGF2α for wolfberry group (n = 22) and control group (n = 18) of randomized controlled trial. Values are means with error bars representing the SD. Data analyzed with two-way mixed model ANOVA and post-hoc simple effects test by Bonferroni’s multiple contrasts. * p < 0.05 compared to the corresponding week 0 values. At week 0, there were no significant differences in plasma MDA (p = 0.42) and 8-isoPGF2α (p = 0.82). Abbreviations: MDA, malondialdehyde; 8-isoPGF2α, 8-iso-prostaglandin F2α.

Figure 3

Figure 3

Skin carotenoids status for wolfberry group (n = 22) and control group (n = 18) at 4-week intervals of randomized controlled trial. Values are means with error bars representing the corresponding standard errors of mean. Data analyzed with two-way mixed model ANOVA and post-hoc simple effects test by Bonferroni’s multiple contrasts. * p < 0.05 compared to the corresponding week 0 values. Skin carotenoids status was not significantly different between groups at week 0 according to independent t-tests (p = 0.98).

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