Nephrotoxicity of Herbal Products in Europe-A Review of an Underestimated Problem - PubMed (original) (raw)

Review

Nephrotoxicity of Herbal Products in Europe-A Review of an Underestimated Problem

Katarzyna Kiliś-Pstrusińska et al. Int J Mol Sci. 2021.

Abstract

Currently in Europe, despite the many advances in production technology of synthetic drugs, the interest in natural herbal medicines continues to increase. One of the reasons for their popular use is the assumption that natural equals safe. However, herbal medicines contain pharmacologically active ingredients, some of which have been associated with adverse effects. Kidneys are particularly susceptible to injury induced by toxins, including poisonous constituents from medicinal plants. The most recognized herb-induced kidney injury is aristolochic acid nephropathy connected with misuse of certain Traditional Chinese herbal medicines. Data concerning nephrotoxicity of plant species of European origin are scarce. Here, we critically review significant data of the nephrotoxicity of several plants used in European phytotherapy, including Artemisia herba-alba, Glycyrrhiza glabra, Euphorbia paralias, and Aloe). Causative mechanisms and factors predisposing to intoxications from the use of herbs are discussed. The basic intention of this review is to improve pharmacovigilance of herbal medicine, especially in patients with chronic kidney diseases.

Keywords: herbal products; nephrotoxicity; pharmacovigilance.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. 1. WHO . WHO Traditional Medicine Strategy 2014–2023. World Health Organization; Geneva, Switzerland: 2013. [(accessed on 23 January 2021)]. Available online: https://www.who.int/medicines/publications/traditional/trm_strategy14_23...
2. 1. Balaraman R., Parmar G., Maheshwari R.A., Anuj S.D. A Review on the Biological Effects of some Natural Products. J. Nat. Remedies. 2020;20:117–127. doi: 10.18311/jnr/2020/25581. - DOI
3. 1. Perazella M.A. Renal vulnerability to drug toxicity. Clin. J. Am. Soc. Nephrol. 2009;4:1275–1283. doi: 10.2215/CJN.02050309. - DOI - PubMed
4. 1. Abuelo J.G. Renal failure caused by chemicals, foods, plants, animal venoms, and misuse of drugs. An overview. Arch. Intern. Med. 1990;150:505–510. doi: 10.1001/archinte.1990.00390150019004. - DOI - PubMed
5. 1. Uber A.M., Sutherland S.M. Nephrotoxins and nephrotoxic acute kidney injury. Pediatr. Nephrol. 2020;35:1825–1833. doi: 10.1007/s00467-019-04397-2. - DOI - PubMed

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