Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis - PubMed (original) (raw)

Review

. 2021 Nov;14(6):1247-1258.

doi: 10.1038/s41385-021-00413-7. Epub 2021 May 26.

Affiliations

• PMID: 34040155
• DOI: 10.1038/s41385-021-00413-7

Free article

Review

Crosstalk between the oral microbiota, mucosal immunity, and the epithelial barrier regulates oral mucosal disease pathogenesis

Dongjia Lin et al. Mucosal Immunol. 2021 Nov.

Free article

Abstract

Oral mucosal disease (OMD), which is also called soft tissue oral disease, is described as a series of disorders or conditions affecting the mucosa and soft tissue in the oral cavity. Its etiology is unclear, but emerging evidence has implicated the influence of the composition of the oral mucosa and saliva-resident microbiota. In turn, this dysbiosis effects the immune response balance and epithelial barrier function, followed by the occurrence and progression of OMD. In addition, oral microbial dysbiosis is diverse in different types of diseases and different disease progressions, suggesting that key causal pathogens may exist in various oral pathologies. This narrative literature review primarily discusses the most recent findings focusing on how microbial dysbiosis communicates with mucosal adaptive immune cells and the epithelial barrier in the context of five representative OMDs, including oral candidiasis (OC), oral lichen planus (OLP), recurrent aphthous ulcer (RAU), oral leukoplakia (OLK), and oral squamous cell carcinoma (OSCC), to provide new insight into the pathogenetic mechanisms of OMDs.

© 2021. The Author(s), under exclusive licence to Society for Mucosal Immunology.

PubMed Disclaimer

Similar articles

• Armed to the Teeth-The Oral Mucosa Immunity System and Microbiota.
  Ptasiewicz M, Grywalska E, Mertowska P, Korona-Głowniak I, Poniewierska-Baran A, Niedźwiedzka-Rystwej P, Chałas R. Ptasiewicz M, et al. Int J Mol Sci. 2022 Jan 14;23(2):882. doi: 10.3390/ijms23020882. Int J Mol Sci. 2022. PMID: 35055069 Free PMC article. Review.
• An Overview of Physical, Microbiological and Immune Barriers of Oral Mucosa.
  Şenel S. Şenel S. Int J Mol Sci. 2021 Jul 22;22(15):7821. doi: 10.3390/ijms22157821. Int J Mol Sci. 2021. PMID: 34360589 Free PMC article. Review.
• The Intestinal Epithelium: Central Coordinator of Mucosal Immunity.
  Allaire JM, Crowley SM, Law HT, Chang SY, Ko HJ, Vallance BA. Allaire JM, et al. Trends Immunol. 2018 Sep;39(9):677-696. doi: 10.1016/j.it.2018.04.002. Epub 2018 Apr 30. Trends Immunol. 2018. PMID: 29716793 Review.
• Oral Versus Gastrointestinal Mucosal Immune Niches in Homeostasis and Allostasis.
  Suárez LJ, Arboleda S, Angelov N, Arce RM. Suárez LJ, et al. Front Immunol. 2021 Jul 5;12:705206. doi: 10.3389/fimmu.2021.705206. eCollection 2021. Front Immunol. 2021. PMID: 34290715 Free PMC article. Review.
• Mucosal IgA Prevents Commensal Candida albicans Dysbiosis in the Oral Cavity.
  Millet N, Solis NV, Swidergall M. Millet N, et al. Front Immunol. 2020 Oct 22;11:555363. doi: 10.3389/fimmu.2020.555363. eCollection 2020. Front Immunol. 2020. PMID: 33193324 Free PMC article.

Cited by

• Research Progress of Polydopamine Hydrogel in the Prevention and Treatment of Oral Diseases.
  Zhou Y, Yang Y, Liu R, Zhou Q, Lu H, Zhang W. Zhou Y, et al. Int J Nanomedicine. 2023 May 16;18:2623-2645. doi: 10.2147/IJN.S407044. eCollection 2023. Int J Nanomedicine. 2023. PMID: 37213351 Free PMC article. Review.
• Oral microbiome in human health and diseases.
  Tian S, Ding T, Li H. Tian S, et al. mLife. 2024 Sep 16;3(3):367-383. doi: 10.1002/mlf2.12136. eCollection 2024 Sep. mLife. 2024. PMID: 39359681 Free PMC article. Review.
• Assessing oral and toothbrush microbial profiles among high-altitude individuals with and without periodontal disease: a case-control study.
  Lei S, Khan I, Zhang X, Chen T, Xie X, Zheng X, Jianye Z, Li Z. Lei S, et al. BMC Oral Health. 2024 Aug 24;24(1):993. doi: 10.1186/s12903-024-04603-0. BMC Oral Health. 2024. PMID: 39182077 Free PMC article.
• Aphthous stomatitis - computational biology suggests external biotic stimulus and immunogenic cell death involved.
  Riveros-Gomez I, Vasquez-Marin J, Huerta-Garcia EX, Camargo-Ayala PA, Rivera C. Riveros-Gomez I, et al. BMC Oral Health. 2024 Sep 29;24(1):1154. doi: 10.1186/s12903-024-04917-z. BMC Oral Health. 2024. PMID: 39343890 Free PMC article.
• Interleukin-35 -producing B cells rescues inflammatory bowel disease in a mouse model via STAT3 phosphorylation and intestinal microbiota modification.
  Xie M, Zhu Y, Zhou Y, Wang Q, Gu E, Chu Y, Wang L. Xie M, et al. Cell Death Discov. 2023 Feb 17;9(1):67. doi: 10.1038/s41420-023-01366-5. Cell Death Discov. 2023. PMID: 36797242 Free PMC article.

References

1. 1. Vila, T., Sultan, A. S., Montelongo-Jauregui, D. & Jabra-Rizk, M. A. Oral candidiasis: a disease of opportunity. J. Fungi. 6, 15 (2020). - DOI
2. 1. Alrashdan, M. S., Cirillo, N. & McCullough, M. Oral lichen planus: a literature review and update. Arch. Dermatol Res. 308, 539–551 (2016). - DOI - PubMed
3. 1. Rivera, C. Essentials of recurrent aphthous stomatitis. Biomed. Rep. 11, 47–50 (2019). - PubMed - PMC
4. 1. Ojeda, D., Huber, M. A. & Kerr, A. R. Oral potentially malignant disorders and oral cavity cancer. Dermatol Clin. 38, 507–521 (2020). - DOI - PubMed
5. 1. Chen, Q., Zeng X. Case Based Oral Mucosal Diseases. 1st edn (Springer Nature Singapore Pte Ltd., Beijing, 2018).

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • ClinicalKey
  • Elsevier Science

• Other Literature Sources

  • scite Smart Citations