Relaxation of isolated ventricular cardiomyocytes by a voltage-dependent process - PubMed (original) (raw)
. 1988 Aug 12;241(4867):823-5.
doi: 10.1126/science.3406740.
Affiliations
- PMID: 3406740
- DOI: 10.1126/science.3406740
Relaxation of isolated ventricular cardiomyocytes by a voltage-dependent process
J H Bridge et al. Science. 1988.
Erratum in
- Science 1988 Dec 9;242(4884):1361
Abstract
Cell contraction and relaxation were measured in single voltage-clamped guinea pig cardiomyocytes to investigate the contribution of sarcolemmal Na+-Ca2+ exchange to mechanical relaxation. Cells clamped from -80 to 0 millivolts displayed initial phasic and subsequent tonic contractions; caffeine reduced or abolished the phasic and enlarged the tonic contraction. The rate of relaxation from tonic contractions was steeply voltage-dependent and was significantly slowed in the absence of a sarcolemmal Na+ gradient. Tonic contractions elicited in the absence of a Na+ gradient promptly relaxed when external Na+ was applied, reflecting activation of Na+-Ca2+ exchange. It appears that a voltage-dependent Na+-Ca2+ exchange can rapidly mechanically relax mammalian heart muscle.
Similar articles
- Regulation of unloaded cell shortening by sarcolemmal sodium-calcium exchange in isolated rat ventricular myocytes.
Bouchard RA, Clark RB, Giles WR. Bouchard RA, et al. J Physiol. 1993 Sep;469:583-99. doi: 10.1113/jphysiol.1993.sp019831. J Physiol. 1993. PMID: 8271217 Free PMC article. - Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes.
Janczewski AM, Lakatta EG. Janczewski AM, et al. J Physiol. 1993 Nov;471:343-63. doi: 10.1113/jphysiol.1993.sp019904. J Physiol. 1993. PMID: 8120810 Free PMC article. - Voltage dependent activation of tonic contraction in cardiac myocytes.
Mackiewicz U, Emanuel K, Lewartowski B. Mackiewicz U, et al. J Physiol Pharmacol. 2003 Sep;54(3):409-21. J Physiol Pharmacol. 2003. PMID: 14566079 - Effects of thapsigargin in normal and pretreated with ryanodine guinea pig cardiomyocytes.
Lewartowski B, Rózycka M, Janiak R. Lewartowski B, et al. Am J Physiol. 1994 May;266(5 Pt 2):H1829-39. doi: 10.1152/ajpheart.1994.266.5.H1829. Am J Physiol. 1994. PMID: 8203582 - Control of cardiac contractility at the cellular level.
Chapman RA. Chapman RA. Am J Physiol. 1983 Oct;245(4):H535-52. doi: 10.1152/ajpheart.1983.245.4.H535. Am J Physiol. 1983. PMID: 6353942 Review.
Cited by
- Rapid inhibition of the Na+-K+ pump affects Na+-Ca2+ exchanger-mediated relaxation in rabbit ventricular myocytes.
Terracciano CM. Terracciano CM. J Physiol. 2001 May 15;533(Pt 1):165-73. doi: 10.1111/j.1469-7793.2001.0165b.x. J Physiol. 2001. PMID: 11351025 Free PMC article. - Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia.
Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B. Chudin E, et al. Biophys J. 1999 Dec;77(6):2930-41. doi: 10.1016/S0006-3495(99)77126-2. Biophys J. 1999. PMID: 10585917 Free PMC article. - Na-Ca exchange and the trigger for sarcoplasmic reticulum Ca release: studies in adult rabbit ventricular myocytes.
Litwin SE, Li J, Bridge JH. Litwin SE, et al. Biophys J. 1998 Jul;75(1):359-71. doi: 10.1016/S0006-3495(98)77520-4. Biophys J. 1998. PMID: 9649393 Free PMC article. - Na+ current and Ca2+ release from the sarcoplasmic reticulum during action potentials in guinea-pig ventricular myocytes.
Sipido KR, Carmeliet E, Pappano A. Sipido KR, et al. J Physiol. 1995 Nov 15;489 ( Pt 1)(Pt 1):1-17. doi: 10.1113/jphysiol.1995.sp021025. J Physiol. 1995. PMID: 8583394 Free PMC article. - Regulation of unloaded cell shortening by sarcolemmal sodium-calcium exchange in isolated rat ventricular myocytes.
Bouchard RA, Clark RB, Giles WR. Bouchard RA, et al. J Physiol. 1993 Sep;469:583-99. doi: 10.1113/jphysiol.1993.sp019831. J Physiol. 1993. PMID: 8271217 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous