Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport - PubMed (original) (raw)
Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport
G M Knudsen et al. J Hepatol. 1988 Apr.
Abstract
Blood-brain barrier permeability to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), to sucrose and to sodium was studied in rats with galactosamine-induced liver damage and hepatic encephalopathy by means of an arterial integral uptake technique. Permeability to GABA was unaltered in all examined brain regions (2.47 +/- 0.25.10(-5) cm3.s-1.g-1, mean +/- S.D.) as compared to control rats (2.49 +/- 0.19.10(-5) cm3.s-1.g-1). The permeability to sucrose (galactosamine 0.25 +/- 0.02 vs. controls 0.24 +/- 0.02.10(-5) cm3.s-1.g-1) and to sodium (galactosamine 5.33 +/- 0.04 vs. controls 5.40 +/- 0.05.10(-5) cm3.s-1.g-1) was also unchanged in hepatic encephalopathy. At the time of investigation mean liver function measured by antipyrine clearance was reduced from 0.39 in control rats to 0.23 ml/min/100 g body wt. in galactosamine-treated animals. The present study does not support the suggestion that peripheral GABA penetrates the blood-brain barrier to any higher extent in hepatic encephalopathy. This provides evidence against at least part of the GABA-hypothesis. Furthermore, an unspecific increased blood-brain barrier permeability in hepatic encephalopathy, as measured by sucrose and sodium uptake, was not found. It is concluded that the GABA-theory requires further careful reevaluation.
Similar articles
- Metabolism and brain uptake of gamma-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats.
Zeneroli ML, Iuliano E, Racagni G, Baraldi M. Zeneroli ML, et al. J Neurochem. 1982 May;38(5):1219-22. doi: 10.1111/j.1471-4159.1982.tb07893.x. J Neurochem. 1982. PMID: 7062047 - Increased brain uptake of gamma-aminobutyric acid in a rabbit model of hepatic encephalopathy.
Bassett ML, Mullen KD, Scholz B, Fenstermacher JD, Jones EA. Bassett ML, et al. Gastroenterology. 1990 Mar;98(3):747-57. doi: 10.1016/0016-5085(90)90298-f. Gastroenterology. 1990. PMID: 2298374 - The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability.
Lo WD, Ennis SR, Goldstein GW, McNeely DL, Betz AL. Lo WD, et al. Hepatology. 1987 May-Jun;7(3):452-6. doi: 10.1002/hep.1840070307. Hepatology. 1987. PMID: 3570156 - Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint.
Ahboucha S, Butterworth RF. Ahboucha S, et al. Metab Brain Dis. 2004 Dec;19(3-4):331-43. doi: 10.1023/b:mebr.0000043979.58915.41. Metab Brain Dis. 2004. PMID: 15554425 Review. - The GABA hypothesis of the pathogenesis of hepatic encephalopathy: current status.
Jones EA, Schafer DF, Ferenci P, Pappas SC. Jones EA, et al. Yale J Biol Med. 1984 May-Jun;57(3):301-16. Yale J Biol Med. 1984. PMID: 6093394 Free PMC article. Review.
Cited by
- Neurotransmitters as food supplements: the effects of GABA on brain and behavior.
Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Boonstra E, et al. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. Front Psychol. 2015. PMID: 26500584 Free PMC article. Review. - Protocol for a pilot and feasibility randomized-controlled trial of four weeks of oral γ-aminobutyric acid (GABA) intake and its effect on pain and sleep in middle-to-older aged adults.
Montesino-Goicolea S, Nin O, Gonzalez BM, Sawczuk NJ, Nodarse CL, Valdes-Hernandez PA, Jackson E, Huo Z, Somerville JET, Porges EC, Smith C, Fillingim RB, Cruz-Almeida Y. Montesino-Goicolea S, et al. Contemp Clin Trials Commun. 2023 Jan 20;32:101066. doi: 10.1016/j.conctc.2023.101066. eCollection 2023 Apr. Contemp Clin Trials Commun. 2023. PMID: 36712186 Free PMC article. - From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators.
Han H, Yi B, Zhong R, Wang M, Zhang S, Ma J, Yin Y, Yin J, Chen L, Zhang H. Han H, et al. Microbiome. 2021 Jul 20;9(1):162. doi: 10.1186/s40168-021-01093-y. Microbiome. 2021. PMID: 34284827 Free PMC article. Review. - Neurochemistry of hepatic encephalopathy.
Record CO. Record CO. Gut. 1991 Nov;32(11):1261-3. doi: 10.1136/gut.32.11.1261. Gut. 1991. PMID: 1752451 Free PMC article. Review. No abstract available. - Effect of oral administration of GABA on thermoregulation in athletes during exercise in cold environments: A preliminary study.
Wang H, Cheng L, Han Y. Wang H, et al. Front Nutr. 2022 Jul 15;9:883571. doi: 10.3389/fnut.2022.883571. eCollection 2022. Front Nutr. 2022. PMID: 35911099 Free PMC article.