Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota - PubMed (original) (raw)

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Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota

Renuka R Nayak. J Invest Dermatol. 2021 Jul.

Abstract

Shi et al. (2021) in "Short-term Western diet intake promotes IL-23-mediated skin and joint inflammation accompanied by changes to the gut microbiota in mice" show that Western diet (WD) exacerbates an IL-23 minicircle‒mediated model of psoriasis and psoriatic arthritis, with an expansion of IL-17A‒expressing γδ T cells and shifts to the gut microbial community. WD-associated inflammation is mitigated by diet manipulation or antibiotic administration. These results suggest that dietary manipulation may be useful in the treatment of IL-23‒mediated disease, possibly through the modulation of the gut microbiota.

Copyright © 2021 The Author. Published by Elsevier Inc. All rights reserved.

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CONFLICT OF INTEREST

The author states no conflict of interest.

Figures

Figure 1.. Western diet-induced exacerbation of IL-23 mediated skin and joint disease can be mitigated with antibiotics or diet manipulation.

Mice treated with (a) IL-23 minicircle DNA and placed on a (b) WD developed (c) worse psoriatic-like skin and joint disease accompanied by changes to the gut microbiota. In contrast, those fed a (d) CD exhibited (e) less severe skin and joint disease. Treatment of WD-fed mice with either (f) antibiotics or a switch to a CD alleviated disease. CD, conventional diet; WD, western diet.

Comment on

• Short-Term Western Diet Intake Promotes IL-23‒Mediated Skin and Joint Inflammation Accompanied by Changes to the Gut Microbiota in Mice.
  Shi Z, Wu X, Santos Rocha C, Rolston M, Garcia-Melchor E, Huynh M, Nguyen M, Law T, Haas KN, Yamada D, Millar NL, Wan YY, Dandekar S, Hwang ST. Shi Z, et al. J Invest Dermatol. 2021 Jul;141(7):1780-1791. doi: 10.1016/j.jid.2020.11.032. Epub 2021 Jan 22. J Invest Dermatol. 2021. PMID: 33485880 Free PMC article.

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