Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice - PubMed (original) (raw)

Effect of the gastrointestinal microflora on induction and maintenance of oral tolerance to ovalbumin in C3H/HeJ mice

M C Moreau et al. Infect Immun. 1988 Oct.

Abstract

The effect of the digestive microflora on oral tolerance to ovalbumin was studied by using axenic (germfree) and conventional C3H/HeJ mice. In contrast to reported results of studies with sheep erythrocytes, oral administration of ovalbumin induced tolerance in axenic mice, but the maintenance of tolerance was found to be of shorter duration than was with conventional mice. These data indicate that the contribution of the microflora to oral tolerance depends on the antigen used.

PubMed Disclaimer

Similar articles

• Colonization of gnotobiotic mice with human gut microflora at birth protects against Escherichia coli heat-labile enterotoxin-mediated abrogation of oral tolerance.
  Gaboriau-Routhiau V, Raibaud P, Dubuquoy C, Moreau MC. Gaboriau-Routhiau V, et al. Pediatr Res. 2003 Nov;54(5):739-46. doi: 10.1203/01.PDR.0000086902.52137.C9. Epub 2003 Aug 6. Pediatr Res. 2003. PMID: 12904595
• The absence of gut flora, the doses of antigen ingested and aging affect the long-term peripheral tolerance induced by ovalbumin feeding in mice.
  Moreau MC, Gaboriau-Routhiau V. Moreau MC, et al. Res Immunol. 1996 Jan;147(1):49-59. doi: 10.1016/0923-2494(96)81548-3. Res Immunol. 1996. PMID: 8739328
• Oral tolerance to ovalbumin in mice: effect of some parameters on the induction and persistence of the suppression of systemic IgE and IgG antibody responses.
  Moreau MC, Coste M, Gaboriau V, Dubuquoy C. Moreau MC, et al. Adv Exp Med Biol. 1995;371B:1229-34. Adv Exp Med Biol. 1995. PMID: 7502789 No abstract available.
• Role of intestinal bacterial flora in oral tolerance induction.
  Tanaka K, Ishikawa H. Tanaka K, et al. Histol Histopathol. 2004 Jul;19(3):907-14. doi: 10.14670/HH-19.907. Histol Histopathol. 2004. PMID: 15168353 Review.

Cited by

• Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic cells.
  Karlsson H, Larsson P, Wold AE, Rudin A. Karlsson H, et al. Infect Immun. 2004 May;72(5):2671-8. doi: 10.1128/IAI.72.5.2671-2678.2004. Infect Immun. 2004. PMID: 15102775 Free PMC article.
• The microbiome and regulation of mucosal immunity.
  McDermott AJ, Huffnagle GB. McDermott AJ, et al. Immunology. 2014 May;142(1):24-31. doi: 10.1111/imm.12231. Immunology. 2014. PMID: 24329495 Free PMC article. Review.
• An expanding stage for commensal microbes in host immune regulation.
  Shi Y, Mu L. Shi Y, et al. Cell Mol Immunol. 2017 Apr;14(4):339-348. doi: 10.1038/cmi.2016.64. Epub 2017 Jan 9. Cell Mol Immunol. 2017. PMID: 28065939 Free PMC article. Review.
• Innate immune responses of human neonatal cells to bacteria from the normal gastrointestinal flora.
  Karlsson H, Hessle C, Rudin A. Karlsson H, et al. Infect Immun. 2002 Dec;70(12):6688-96. doi: 10.1128/IAI.70.12.6688-6696.2002. Infect Immun. 2002. PMID: 12438343 Free PMC article.
• Successful transmission of a retrovirus depends on the commensal microbiota.
  Kane M, Case LK, Kopaskie K, Kozlova A, MacDearmid C, Chervonsky AV, Golovkina TV. Kane M, et al. Science. 2011 Oct 14;334(6053):245-9. doi: 10.1126/science.1210718. Science. 2011. PMID: 21998394 Free PMC article.

References

1. 1. Eur J Immunol. 1974 Jun;4(6):435-43 - PubMed
2. 1. J Allergy Clin Immunol. 1977 Aug;60(2):110-5 - PubMed
3. 1. J Immunol. 1978 Mar;120(3):861-5 - PubMed
4. 1. J Immunol. 1978 Nov;121(5):1878-83 - PubMed
5. 1. J Immunol. 1978 Dec;121(6):2429-34 - PubMed

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Europe PubMed Central
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)