The mas oncogene encodes an angiotensin receptor - PubMed (original) (raw)
. 1988 Sep 29;335(6189):437-40.
doi: 10.1038/335437a0.
Affiliations
- PMID: 3419518
- DOI: 10.1038/335437a0
The mas oncogene encodes an angiotensin receptor
T R Jackson et al. Nature. 1988.
Abstract
The class of receptors coupled to GTP-binding proteins share a conserved structural motif which is described as a 'seven-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. Identified examples include the mammalian opsins, alpha 1-, alpha 2-, beta 1- and beta 2-adrenergic receptors, the muscarinic receptor family, the 5-HT1C-receptor, and the substance-K receptor. In addition, two mammalian genes have been identified that code for predicted gene products with sequence similarity to these receptors, but whose ligand specificity is unknown namely, G21 and the mas oncogene. The mas oncogene shows the greatest sequence similarity to the substance-K receptor, and on this basis it was predicted that it would encode a peptide receptor with mitogenic activity which would act through the inositol lipid signalling pathways. The mas oncogene product was transiently expressed in Xenopus oocytes, and stably expressed in a transfected mammalian cell line. The results demonstrate that the mas gene product is a functional angiotensin receptor.
Similar articles
- Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions.
Monnot C, Weber V, Stinnakre J, Bihoreau C, Teutsch B, Corvol P, Clauser E. Monnot C, et al. Mol Endocrinol. 1991 Oct;5(10):1477-87. doi: 10.1210/mend-5-10-1477. Mol Endocrinol. 1991. PMID: 1723144 - The mas oncogene as a neural peptide receptor: expression, regulation and mechanism of action.
Hanley MR, Cheung WT, Hawkins P, Poyner D, Benton HP, Blair L, Jackson TR, Goedert M. Hanley MR, et al. Ciba Found Symp. 1990;150:23-38; discussion 38-46. doi: 10.1002/9780470513927.ch3. Ciba Found Symp. 1990. PMID: 2197067 Review. - Isolation and expression of a novel angiotensin II receptor from Xenopus laevis heart.
Bergsma DJ, Ellis C, Nuthulaganti PR, Nambi P, Scaife K, Kumar C, Aiyar N. Bergsma DJ, et al. Mol Pharmacol. 1993 Aug;44(2):277-84. Mol Pharmacol. 1993. PMID: 8355665 - Functional rescue of a defective angiotensin II AT1 receptor mutant by the Mas protooncogene.
Santos EL, Reis RI, Silva RG, Shimuta SI, Pecher C, Bascands JL, Schanstra JP, Oliveira L, Bader M, Paiva AC, Costa-Neto CM, Pesquero JB. Santos EL, et al. Regul Pept. 2007 Jun 7;141(1-3):159-67. doi: 10.1016/j.regpep.2006.12.030. Epub 2007 Jan 20. Regul Pept. 2007. PMID: 17320985
Cited by
- Orphan G protein-coupled receptors: the ongoing search for a home.
Jobe A, Vijayan R. Jobe A, et al. Front Pharmacol. 2024 Feb 29;15:1349097. doi: 10.3389/fphar.2024.1349097. eCollection 2024. Front Pharmacol. 2024. PMID: 38495099 Free PMC article. Review. - Alternative Renin-Angiotensin System.
Bader M, Steckelings UM, Alenina N, Santos RAS, Ferrario CM. Bader M, et al. Hypertension. 2024 May;81(5):964-976. doi: 10.1161/HYPERTENSIONAHA.123.21364. Epub 2024 Feb 16. Hypertension. 2024. PMID: 38362781 Review. - The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons.
Franco R, Serrano-Marín J, Navarro G, Rivas-Santisteban R. Franco R, et al. Antioxidants (Basel). 2023 Oct 16;12(10):1869. doi: 10.3390/antiox12101869. Antioxidants (Basel). 2023. PMID: 37891948 Free PMC article. Review. - Mas receptor: a potential strategy in the management of ischemic cardiovascular diseases.
Molaei A, Molaei E, Hayes AW, Karimi G. Molaei A, et al. Cell Cycle. 2023 Jul;22(13):1654-1674. doi: 10.1080/15384101.2023.2228089. Epub 2023 Jun 26. Cell Cycle. 2023. PMID: 37365840 Free PMC article. Review. - G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.
Schmitz GP, Roth BL. Schmitz GP, et al. Am J Physiol Cell Physiol. 2023 Jul 1;325(1):C17-C28. doi: 10.1152/ajpcell.00397.2022. Epub 2023 Apr 17. Am J Physiol Cell Physiol. 2023. PMID: 37067459 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases