Precision Repetitive Transcranial Magnetic Stimulation Over the Left Parietal Cortex Improves Memory in Alzheimer's Disease: A Randomized, Double-Blind, Sham-Controlled Study - PubMed (original) (raw)

doi: 10.3389/fnagi.2021.693611. eCollection 2021.

Luoyi Xu 1, Kehua Yang 1, Yingchun Zhang 1, Xinghui Lv 1, Zhenwei Zhu 1, Zheli Chen 2, Yunlong Zhu 3, Lili Wei 1, Xia Li 4, Mincai Qian 2, Yuedi Shen 5, Weiming Hu 3, Wei Chen 1 6 7

Affiliations

Precision Repetitive Transcranial Magnetic Stimulation Over the Left Parietal Cortex Improves Memory in Alzheimer's Disease: A Randomized, Double-Blind, Sham-Controlled Study

Yanli Jia et al. Front Aging Neurosci. 2021.

Abstract

Objective: We aim to study the effect of precision repetitive transcranial magnetic stimulation (rTMS) over the left parietal cortex on the memory and cognitive function in Alzheimer's disease (AD).

Methods: Based on the resting-state functional magnetic resonance imaging, the left parietal cortex site with the highest functional connectivity to the hippocampus was selected as the target of rTMS treatment. Sixty-nine AD patients were randomized to either rTMS or sham treatment (five sessions/week for a total of 10 sessions). The Mini-Mental State Examination (MMSE), 12-Word Philadelphia Verbal Learning Test (PVLT), and Clinical Dementia Rating (CDR) were assessed at baseline and after the last session.

Results: After a 2-week treatment, compared to patients in the sham group, those in the rTMS group scored significantly higher on PVLT total score and its immediate recall subscale score. Moreover, in the rTMS group, there were significant improvements after the 2-week treatment, which were manifested in MMSE total score and its time orientation and recall subscale scores, as well as PVLT total score and its immediate recall and short delay recall subscale scores. In the sham group, the PVLT total score was significantly improved.

Conclusion: The target site of the left parietal cortex can improve AD patients' cognitive function, especially memory, providing a potential therapy.

Keywords: Alzheimer’s disease; cognition; left parietal cortex; memory; precision rTMS.

Copyright © 2021 Jia, Xu, Yang, Zhang, Lv, Zhu, Chen, Zhu, Wei, Li, Qian, Shen, Hu and Chen.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer TC declared a shared affiliation, with no collaboration, with one of the authors XLi to the handling editor at the time of the review.

Figures

FIGURE 1

FIGURE 1

CONSORT diagram of patients with Alzheimer’s disease in a double-blind, sham-controlled study of rTMS.

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