Oxidative stress in the skin: Impact and related protection - PubMed (original) (raw)
Review
. 2021 Oct;43(5):495-509.
doi: 10.1111/ics.12728. Epub 2021 Aug 28.
Affiliations
- PMID: 34312881
- DOI: 10.1111/ics.12728
Review
Oxidative stress in the skin: Impact and related protection
Juanjuan Chen et al. Int J Cosmet Sci. 2021 Oct.
Abstract
Skin, our first interface to the external environment, is subjected to oxidative stress caused by a variety of factors such as solar ultraviolet, infrared and visible light, environmental pollution, including ozone and particulate matters, and psychological stress. Excessive reactive species, including reactive oxygen species and reactive nitrogen species, exacerbate skin pigmentation and aging, which further lead to skin tone unevenness, pigmentary disorder, skin roughness and wrinkles. Besides these, skin microbiota are also a very important factor ensuring the proper functions of skin. While environmental factors such as UV and pollutants impact skin microbiota compositions, skin dysbiosis results in various skin conditions. In this review, we summarize the generation of oxidative stress from exogenous and endogenous sources. We further introduce current knowledge on the possible roles of oxidative stress in skin pigmentation and aging, specifically with emphasis on oxidative stress and skin pigmentation. Meanwhile, we summarize the science and rationale of using three well-known antioxidants, namely vitamin C, resveratrol and ferulic acid, in the treatment of hyperpigmentation. Finally, we discuss the strategy for preventing oxidative stress-induced skin pigmentation and aging.
La peau, notre première interface avec l’environnement externe, est soumise à un stress oxydatif causé par divers facteurs tels que les ultraviolets solaires, l’infrarouge et la lumière visible, la pollution environnementale, y compris l’ozone et les particules, et le stress psychologique. Les espèces réactives excessives, y compris les espèces réactives de l’oxygène et les espèces réactives de l’azote, exacerbent la pigmentation et le vieillissement de la peau, ce qui entraîne une irrégularité du teint, un trouble pigmentaire, de la rugosité de la peau et des rides. De plus, le microbiote cutané est également un facteur très important pour assurer le bon fonctionnement de la peau. Alors que les facteurs environnementaux tels que les UV et les polluants ont un impact sur les compositions du microbiote cutané, la dysbiose cutanée entraîne diverses affections cutanées. Dans cette revue, nous résumons la production du stress oxydatif à partir de sources exogènes et endogènes. Nous introduisons également les connaissances actuelles sur les rôles possibles du stress oxydatif dans la pigmentation et le vieillissement de la peau, en particulier sur le stress oxydatif et la pigmentation de la peau. Pendant ce temps, nous résumons la science et la justification de l’utilisation de trois antioxydants bien connus, à savoir la vitamine C, le resvératrol, et l’acide férulique, dans le traitement de l’hyperpigmentation. Enfin, nous discutons de la stratégie de prévention de la pigmentation et du vieillissement de la peau induits par le stress oxydatif.
Keywords: antioxidants; environmental pollution; microbiome; oxidative stress; skin pigmentation.
© 2021 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
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