A low serum IGF-1 is correlated with sarcopenia in subjects with type 1 diabetes mellitus: Findings from a post-hoc analysis of the iDIAMOND study - PubMed (original) (raw)

doi: 10.1016/j.diabres.2021.108998. Epub 2021 Aug 11.

Hiroyasu Mori 2, Tetsuyuki Yasuda 1, Yoko Irie 1, Tsunehiko Yamamoto 3, Yutaka Umayahara 4, Kayoko Ryomoto 5, Kazutomi Yoshiuchi 6, Sumiko Yoshida 7, Iichiro Shimomura 8, Akio Kuroda 2, Munehide Matsuhisa 9

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A low serum IGF-1 is correlated with sarcopenia in subjects with type 1 diabetes mellitus: Findings from a post-hoc analysis of the iDIAMOND study

Sonyun Hata et al. Diabetes Res Clin Pract. 2021 Sep.

Abstract

Aim: Our previous study revealed that sarcopenia was frequently observed in subjects with type 1 diabetes mellitus (T1DM). However, the factors associated with sarcopenia that are related to T1DM have not yet been clarified. Insulin-like growth factor-1 (IGF-1) has been shown to play a role in skeletal muscle growth, differentiation, and regeneration. The present study, therefore, investigated the association between the serum IGF-1 level and sarcopenia and low skeletal muscle mass in subjects with T1DM.

Methods: This cross-sectional study enrolled subjects with T1DM (n = 168) and without diabetes (n = 59) who had had their clinical data on serum IGF-1 collected in the iDIAMOND study.

Results: The z-score of serum IGF-1 was significantly lower in the subjects with T1DM than that in those without diabetes (p < 0.001). Among subjects with T1DM, the z-score of serum IGF-1 was significantly lower in sarcopenic subjects than in non-sarcopenic subjects. The multivariable logistic regression analysis showed that the serum IGF-1 z-score was an independent determinant of sarcopenia and a low skeletal muscle mass index, but not low grip strength nor slow gait speed in subjects with T1DM.

Conclusions: A low serum IGF-1 level is correlated with sarcopenia and low skeletal muscle mass in subjects with T1DM.

Keywords: Sarcopenia; Serum IGF-1; Skeletal muscle mass; Type 1 diabetes.

Copyright © 2021 Elsevier B.V. All rights reserved.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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