Behavioral effects of phencyclidine and ketamine alone and in combination with other drugs - PubMed (original) (raw)
Behavioral effects of phencyclidine and ketamine alone and in combination with other drugs
L D Byrd et al. Eur J Pharmacol. 1987.
Abstract
The behavioral effects of phencyclidine (PCP) and ketamine administered alone and in combination with naloxone, atropine, methyl atropine, chlorpromazine and d-amphetamine were studied in squirrel monkeys trained to press a response lever under a fixed-ratio 30 schedule maintained by the termination of a stimulus associated with electric shock presentation. Under non-drug conditions, a period of high-rate responding in the presence of the stimulus associated with shock presentation was followed by a period of no responding during a 40-s timeout scheduled between fixed-ratio components. Mean rates of responding during fixed-ratio components decreased monotonically as PCP dose increased from 0.1 to 0.56 mg/kg, and doses of 3.0 and 5.6 mg/kg ketamine produced decreases in mean response rate comparable to doses of 0.3 and 0.56 mg/kg PCP. The dose-effect functions revealed that ketamine was approximately one-tenth as potent as PCP. The present data also characterized the time-course effects of PCP and ketamine, with the former having effects that were slower in onset yet more persistent in time. None of the drugs studied in combination with PCP and ketamine provided evidence of a pharmacological antagonism of the behavioral effects of the latter two drugs. Rather, the data indicated an enhancement of behavioral effects when certain drug combinations were studied.
Similar articles
- Failure of naloxone to modify the effects of chlorpromazine and d-amphetamine on avoidance behavior in the squirrel monkey.
Holtzman SG. Holtzman SG. Psychopharmacology (Berl). 1979 Jun 21;63(3):207-9. doi: 10.1007/BF00433551. Psychopharmacology (Berl). 1979. PMID: 113805 - Effects of phencyclidine, atropine and physostigmine, alone and in combination, on variable-interval performance in the squirrel monkey.
Chait LD, Balster RL. Chait LD, et al. Pharmacol Biochem Behav. 1979 Jul;11(1):37-42. doi: 10.1016/0091-3057(79)90294-6. Pharmacol Biochem Behav. 1979. PMID: 115014 - Discriminative stimulus properties of stereoisomers of cyclazocine in phencyclidine-trained squirrel monkeys.
Brady KT, Balster RL. Brady KT, et al. Life Sci. 1982 Aug 9;31(6):541-9. doi: 10.1016/0024-3205(82)90482-9. Life Sci. 1982. PMID: 6290818 - The effects of phencyclidine, ketamine, delta-amphetamine and pentobarbital on schedule-controlled behavior in the mouse.
Wenger GR, Dews PB. Wenger GR, et al. J Pharmacol Exp Ther. 1976 Mar;196(3):616-24. J Pharmacol Exp Ther. 1976. PMID: 1263116 - Discriminative stimulus properties of phencyclidine and five analogues in the squirrel monkey.
Brady KT, Balster RL. Brady KT, et al. Pharmacol Biochem Behav. 1981 Feb;14(2):213-8. doi: 10.1016/0091-3057(81)90245-8. Pharmacol Biochem Behav. 1981. PMID: 7208560
Cited by
- Examination of clozapine and haloperidol in improving ketamine-induced deficits in an incremental repeated acquisition procedure in BALB/c mice.
Shen AN, Newland MC. Shen AN, et al. Psychopharmacology (Berl). 2016 Feb;233(3):485-98. doi: 10.1007/s00213-015-4120-x. Epub 2015 Oct 29. Psychopharmacology (Berl). 2016. PMID: 26514554 - Ketamine : from medicine to misuse.
Wolff K, Winstock AR. Wolff K, et al. CNS Drugs. 2006;20(3):199-218. doi: 10.2165/00023210-200620030-00003. CNS Drugs. 2006. PMID: 16529526 Review. - Ketamine impairs multiple cognitive domains in rhesus monkeys.
Taffe MA, Davis SA, Gutierrez T, Gold LH. Taffe MA, et al. Drug Alcohol Depend. 2002 Oct 1;68(2):175-87. doi: 10.1016/s0376-8716(02)00194-1. Drug Alcohol Depend. 2002. PMID: 12234647 Free PMC article. - Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine.
Adams B, Moghaddam B. Adams B, et al. J Neurosci. 1998 Jul 15;18(14):5545-54. doi: 10.1523/JNEUROSCI.18-14-05545.1998. J Neurosci. 1998. PMID: 9651235 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources