UK Bacteroides species surveillance survey: Change in antimicrobial resistance over 16 years (2000-2016) - PubMed (original) (raw)
UK Bacteroides species surveillance survey: Change in antimicrobial resistance over 16 years (2000-2016)
Sarah Copsey-Mawer et al. Anaerobe. 2021 Dec.
Abstract
Objectives: To assess the differences in antimicrobial susceptibility of UK Bacteroides species across two distinct cohorts from 2000 to 2016.
Methods: Strain identification was performed using matrix-assisted laser-desorption ionisation time of flight mass spectrometry (MALDI-TOF MS) or by partial 16S rRNA sequencing. Minimum inhibitory concentrations (MICs) were determined using agar dilution, following CLSI guidelines (CLSI, 2012; 2017).
Results: 224 isolates were included from 2000 to 168 from 2016. Bacteroides fragilis was the most common species, comprising 68% of the 2000 cohort, and 77% in 2016. For all antimicrobials tested, there was an overall increase in the rates of non-susceptible isolates between the cohorts.
Conclusions: The antibiogram of Bacteroides species in the UK is no longer predictable. Multi-drug resistant isolates although rare, are on the rise, and require testing to guide therapy. The monitoring and surveillance of resistance trends is imperative, as is the development of standardised, robust and accessible antimicrobial susceptibility testing methodology for clinical laboratories.
Keywords: Antimicrobial resistance; Bacteroides species.
Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of competing interest No conflicts of interest to declare in relation to this manuscript.
Similar articles
- Time for Some Group Therapy: Update on Identification, Antimicrobial Resistance, Taxonomy, and Clinical Significance of the Bacteroides fragilis Group.
Jean S, Wallace MJ, Dantas G, Burnham CD. Jean S, et al. J Clin Microbiol. 2022 Sep 21;60(9):e0236120. doi: 10.1128/jcm.02361-20. Epub 2022 Jun 14. J Clin Microbiol. 2022. PMID: 35700139 Free PMC article. Review. - Molecular characterisation of multidrug-resistant Bacteroides isolates from Hungarian clinical samples.
Sárvári KP, Sóki J, Kristóf K, Juhász E, Miszti C, Melegh SZ, Latkóczy K, Urbán E. Sárvári KP, et al. J Glob Antimicrob Resist. 2018 Jun;13:65-69. doi: 10.1016/j.jgar.2017.10.020. Epub 2017 Oct 31. J Glob Antimicrob Resist. 2018. PMID: 29101081 - Evaluation of VITEK MS, Clin-ToF-II MS, Autof MS 1000 and VITEK 2 ANC card for identification of Bacteroides fragilis group isolates and antimicrobial susceptibilities of these isolates in a Chinese university hospital.
Wang Y, Chen XF, Xie XL, Xiao M, Yang Y, Zhang G, Zhang JJ, Duan SM, Zhang Q, Zhang P, Tsui C, Xu YC. Wang Y, et al. J Microbiol Immunol Infect. 2019 Jun;52(3):456-464. doi: 10.1016/j.jmii.2018.12.009. Epub 2019 Jan 4. J Microbiol Immunol Infect. 2019. PMID: 30772212 - Antimicrobial susceptibility of Bacteroides fragilis group organisms in Hong Kong by the tentative EUCAST disc diffusion method.
Ho PL, Yau CY, Ho LY, Lai EL, Liu MC, Tse CW, Chow KH. Ho PL, et al. Anaerobe. 2017 Oct;47:51-56. doi: 10.1016/j.anaerobe.2017.04.005. Epub 2017 Apr 14. Anaerobe. 2017. PMID: 28414107 - Mechanisms of Bacteroides fragilis resistance to metronidazole.
Ghotaslou R, Bannazadeh Baghi H, Alizadeh N, Yekani M, Arbabi S, Memar MY. Ghotaslou R, et al. Infect Genet Evol. 2018 Oct;64:156-163. doi: 10.1016/j.meegid.2018.06.020. Epub 2018 Jun 21. Infect Genet Evol. 2018. PMID: 29936037 Review.
Cited by
- Anaerobes in diabetic foot infections: pathophysiology, epidemiology, virulence, and management.
Villa F, Marchandin H, Lavigne J-P, Schuldiner S, Cellier N, Sotto A, Loubet P. Villa F, et al. Clin Microbiol Rev. 2024 Sep 12;37(3):e0014323. doi: 10.1128/cmr.00143-23. Epub 2024 May 31. Clin Microbiol Rev. 2024. PMID: 38819166 Review. - Time for Some Group Therapy: Update on Identification, Antimicrobial Resistance, Taxonomy, and Clinical Significance of the Bacteroides fragilis Group.
Jean S, Wallace MJ, Dantas G, Burnham CD. Jean S, et al. J Clin Microbiol. 2022 Sep 21;60(9):e0236120. doi: 10.1128/jcm.02361-20. Epub 2022 Jun 14. J Clin Microbiol. 2022. PMID: 35700139 Free PMC article. Review. - Antimicrobial susceptibility profile of clinically relevant Bacteroides, Phocaeicola, Parabacteroides and Prevotella species, isolated by eight laboratories in the Netherlands.
Boiten KE, Notermans DW, Rentenaar RJ, van Prehn J, Bode LGM, Maat I, van der Zwet W, Jansz A, Siebers TJH, Rossen JWA, de Greeff SC, Hendrickx APA, Kuijper EJ, Veloo ACM. Boiten KE, et al. J Antimicrob Chemother. 2024 Apr 2;79(4):868-874. doi: 10.1093/jac/dkae043. J Antimicrob Chemother. 2024. PMID: 38394460 Free PMC article. - In Vitro Efficacy of Antibiotic Combinations with Carbapenems and Other Agents against Anaerobic Bacteria.
Umemura T, Hagihara M, Mori T, Mikamo H. Umemura T, et al. Antibiotics (Basel). 2022 Feb 22;11(3):292. doi: 10.3390/antibiotics11030292. Antibiotics (Basel). 2022. PMID: 35326756 Free PMC article.