Physical Activity and Risks of Cardiovascular Diseases: A Mendelian Randomization Study - PubMed (original) (raw)

Physical Activity and Risks of Cardiovascular Diseases: A Mendelian Randomization Study

Chengui Zhuo et al. Front Cardiovasc Med. 2021.

Abstract

Background: Although some observational studies have shown that physical activity may have a positive relationship with cardiovascular diseases, the causal effect remains uncertain. We conducted a Mendelian randomization (MR) study to identify the potential causal effect between physical activity and cardiovascular diseases. Methods: Summary statistics of genome-wide association studies on four physical activity phenotypes and cardiovascular diseases were utilized. MR analysis was performed using inverse-variance weighted (IVW) and multivariable MR. Multiple sensitivity analysis was further conducted to identify the robustness of our results. Results: Genetically predicted self-reported vigorous physical activity (VPA) was significantly associated with lower risk of myocardial infarction (IVW OR: 0.24, 95% CI: 0.08-0.68, _p_-value: 0.007). Additionally, the causal effect of VPA with myocardial infarction was robust after adjusting for several cardiovascular risk factors through using the multivariable MR. There were no apparent causal associations between physical activity with other cardiovascular diseases. Results were consistent with the sensitivity analysis. Conclusion: The present study supports a protective role of self-reported vigorous physical activity in the initiation of myocardial infarction and highlights the importance of activity levels of physical activity. Further studies are required to elucidate the potential biological pathways of physical activity with cardiovascular diseases.

Keywords: cardiovascular disease; coronary artery disease; mendelian randomization; myocardial infarction; physical activity.

Copyright © 2021 Zhuo, Zhao, Chen and Lu.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1

Figure 1

A scatter plot for the relationship of self-reported vigorous physical activity with myocardial infarction. A scatter plot of single-nucleotide polymorphism (SNP) effects regarding the associations of genetically predicted self-reported vigorous physical activity (VPA) with myocardial infarction (MI), with the slope of each line corresponding to estimated Mendelian Randomization (MR) effect per method. Circles indicate marginal genetic associations with self-reported vigorous physical activity and risk of myocardial infarction for each variant. Error bars indicate 95% CIs.

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