Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases - PubMed (original) (raw)

Review

. 2022 Mar;72(3):653-676.

doi: 10.1007/s12031-021-01922-7. Epub 2021 Oct 25.

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Review

Emerging Novel Approaches for the Enhanced Delivery of Natural Products for the Management of Neurodegenerative Diseases

Akshay Bandiwadekar et al. J Mol Neurosci. 2022 Mar.

Abstract

Neurodegenerative diseases (NDs) such as Alzheimer's disease, Parkinson's disease, Huntington disease, amyotrophic lateral sclerosis, and prion disease affect any part of the brain. The complete mechanism of ND is unknown, but there are some molecular mechanism and chemical process. Natural compounds have better compatibility with the human body along with lesser side effects. Moreover, several studies showed that various natural compounds have significant neuroprotective, potent antioxidant, and anti-inflammatory properties, which are effective for treating the different type of ND. In ND, natural compounds act by various mechanisms such as preventing the generation of reactive oxygen species (ROS), eliminating destructed biomolecules before their accumulation affects cell metabolism, and improving the disease conditions. But due to the presence of the blood-brain barrier (BBB) layer and unfavorable pharmacokinetic properties of natural compounds, their delivery into the brain is limited. To minimize this problem and enhance drug delivery into the brain with an effective therapeutic dose, there is a need to develop a practical novel approach. The various studies showed that nanoformulations and microneedles (MN) containing natural compounds such as quercetin, curcumin, resveratrol, chrysin, piperine, ferulic acid, huperzine A, berberine, baicalein, hesperetin, and retinoic acid effectively improved many ND. In this review, the effect of such natural drug-loaded nanoformulation and MN patches on ND management is discussed, along with their merits and demerits. This review aims to introduce different novel approaches for enhancing natural drug delivery into the brain to manage various neurodegenerative diseases.

Keywords: Microneedles; Nanoparticle; Natural products; Neurodegenerative diseases.

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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References

    1. Al-Kasasbeh R, Brady AJ, Courtenay AJ et al (2020) Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches. Drug Deliv Transl Res 10:690–705. https://doi.org/10.1007/s13346-020-00727-2 - DOI - PubMed - PMC
    1. Ameen D, Michniak-Kohn B (2017) Transdermal delivery of dimethyl fumarate for Alzheimer’s disease: Effect of penetration enhancers. Int J Pharm 529:465–473. https://doi.org/10.1016/j.ijpharm.2017.07.031 - DOI - PubMed
    1. Amor S, Puentes F, Baker D, Van Der Valk P (2010) Inflammation in neurodegenerative diseases. Immunology 129:154–169 - PubMed - PMC
    1. Anand P, Nair HB, Sung B et al (2010) Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol 79:330–338. https://doi.org/10.1016/j.bcp.2009.09.003 - DOI - PubMed
    1. Arulkumar S, Sabesan M (2012) The behavioral performance tests of Mucuna pruriens gold nanoparticles in the 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine treated mouse model of Parkinsonism. Asian Pac J Trop Dis 2. https://doi.org/10.1016/S2222-1808(12)60210-2

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