Enhancement of epidermal regeneration by biosynthetic epidermal growth factor - PubMed (original) (raw)
Enhancement of epidermal regeneration by biosynthetic epidermal growth factor
G L Brown et al. J Exp Med. 1986.
Abstract
Epidermal regeneration depends on mitosis and migration of keratinocytes. Epidermal growth factor is known to stimulate growth of keratinocytes in vitro, thus it might be expected to promote wound healing. The results of this study show that topical application of biosynthetic human epidermal growth factor accelerates epidermal regeneration in split-thickness wounds and partial-thickness burns. The significant enhancement of epidermal regeneration suggests the potential for clinical use of epidermal growth factor for accelerating healing of burns, wounds from trauma, diabetic ulcers, skin graft donor sites, and others.
Similar articles
- Growth factors in porcine full and partial thickness burn repair. Differing targets and effects of keratinocyte growth factor, platelet-derived growth factor-BB, epidermal growth factor, and neu differentiation factor.
Danilenko DM, Ring BD, Tarpley JE, Morris B, Van GY, Morawiecki A, Callahan W, Goldenberg M, Hershenson S, Pierce GF. Danilenko DM, et al. Am J Pathol. 1995 Nov;147(5):1261-77. Am J Pathol. 1995. PMID: 7485390 Free PMC article. - Enhancement of wound healing by topical treatment with epidermal growth factor.
Brown GL, Nanney LB, Griffen J, Cramer AB, Yancey JM, Curtsinger LJ 3rd, Holtzin L, Schultz GS, Jurkiewicz MJ, Lynch JB. Brown GL, et al. N Engl J Med. 1989 Jul 13;321(2):76-9. doi: 10.1056/NEJM198907133210203. N Engl J Med. 1989. PMID: 2659995 Clinical Trial. - Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor.
Schultz GS, White M, Mitchell R, Brown G, Lynch J, Twardzik DR, Todaro GJ. Schultz GS, et al. Science. 1987 Jan 16;235(4786):350-2. doi: 10.1126/science.3492044. Science. 1987. PMID: 3492044 - EGF and TGF-alpha in wound healing and repair.
Schultz G, Rotatori DS, Clark W. Schultz G, et al. J Cell Biochem. 1991 Apr;45(4):346-52. doi: 10.1002/jcb.240450407. J Cell Biochem. 1991. PMID: 2045428 Review. - [Growth factors and wound healing: review and prospect in recent ten years].
Fu X, Cheng B, Sheng Z. Fu X, et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2004 Nov;18(6):508-12. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2004. PMID: 15586716 Review. Chinese.
Cited by
- The effect of human recombinant epidermal growth factor on neovascularization and pedicle division time in a rat interpolation flap model.
Parspanci A, Keçeci Y, Temiz P. Parspanci A, et al. Turk J Med Sci. 2024 Jan 5;54(2):471-482. doi: 10.55730/1300-0144.5812. eCollection 2024. Turk J Med Sci. 2024. PMID: 39050389 Free PMC article. - Identification of IGF2 promotes skin wound healing by co-expression analysis.
Liu X, Teng Y, Li H, Luo D, Li H, Shen J, Du S, Zhang Y, Wang D, Jing J. Liu X, et al. Int Wound J. 2024 Apr;21(4):e14862. doi: 10.1111/iwj.14862. Int Wound J. 2024. PMID: 38572823 Free PMC article. - An Overview of Recent Developments in the Management of Burn Injuries.
Radzikowska-Büchner E, Łopuszyńska I, Flieger W, Tobiasz M, Maciejewski R, Flieger J. Radzikowska-Büchner E, et al. Int J Mol Sci. 2023 Nov 15;24(22):16357. doi: 10.3390/ijms242216357. Int J Mol Sci. 2023. PMID: 38003548 Free PMC article. Review. - In Vitro and In Vivo Evaluation of Epidermal Growth Factor (EGF) Loaded Alginate-Hyaluronic Acid (AlgHA) Microbeads System for Wound Healing.
Ali M, Kwak SH, Byeon JY, Choi HJ. Ali M, et al. J Funct Biomater. 2023 Jul 28;14(8):403. doi: 10.3390/jfb14080403. J Funct Biomater. 2023. PMID: 37623648 Free PMC article. - Therapeutic role of growth factors in treating diabetic wound.
Zheng SY, Wan XX, Kambey PA, Luo Y, Hu XM, Liu YF, Shan JQ, Chen YW, Xiong K. Zheng SY, et al. World J Diabetes. 2023 Apr 15;14(4):364-395. doi: 10.4239/wjd.v14.i4.364. World J Diabetes. 2023. PMID: 37122434 Free PMC article. Review.
References
- Proc Natl Acad Sci U S A. 1975 Apr;72(4):1317-21 - PubMed
- J Cell Physiol. 1976 Jun;88(2):227-37 - PubMed
- Nature. 1977 Feb 3;265(5593):421-4 - PubMed
- Nature. 1979 Jun 28;279(5716):793-5 - PubMed
- Plast Reconstr Surg. 1979 Dec;64(6):766-70 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical