Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis - PubMed (original) (raw)

Effect of Long-Term Exercise on Liver Lipid Metabolism in Chinese Patients With NAFLD: A Systematic Review and Meta-Analysis

Ye Gao et al. Front Physiol. 2021.

Abstract

Purpose: Using meta-analysis to evaluate the effect of various long-term exercises (more than 4 weeks) on liver lipid metabolism of Chinese patients with non-alcoholic fatty liver disease (NAFLD) and provides more targeted exercise recommendations. Methods: Four databases consisting of PubMed, Web of Science, China Science and Technology Journal Database (VIP), China Knowledge Resource Integrated Database (CNKI) were searched up to May 2021. Randomized controlled trials (RCTs) were eligible, and the outcomes of body composition, lipid metabolism [including triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C)], and liver function [including alanine aminotransferase (ALT) and aspartate aminotransferase (AST)] were used to assess the effectiveness of long-term exercise on Chinese patients with NAFLD. Results: Eleven articles with a total of 13 data points (involving 1,006 participants) satisfied the inclusion criteria and were pooled in the meta-analysis. The findings demonstrated that long-term exercise decreased the level of TG [-0.50, 95%CI (-0.64, -0.36)], TC [-0.55, 95%CI (-0.92, -0.18)], LDL-C [-0.29, 95%CI (-0.43, -0.15)], ALT [-3.45, 95%CI (-6.78, -0.12)], AST [-6.91, 95%CI (-10.00, -3.81)], and body mass index (BMI) of patients who did exercise last more than 6 months [-1.55, 95%CI (-2.32, -0.79)] significantly. The effect on HDL-C was not obvious. Conclusion: Long-term exercise can improve the levels of TG, TC, LDL-C, ALT, and AST in Chinese patients with NAFLD significantly, and exercise last more than 6 months can decrease the BMI of Chinese patients with NAFLD.

Keywords: lipid metabolism; long-term exercise; meta-analysis; non-alcoholic fatty liver disease; systematic review.

Copyright © 2021 Gao, Lu, Liu, Liu, Ma, Shi and Su.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1

Figure 1

Flow diagram of the study selection.

Figure 2

Figure 2

Risk of bias summary of included studies.

Figure 3

Figure 3

Funnel plot of TG.

Figure 4

Figure 4

Funnel plot of TC.

Figure 5

Figure 5

Meta-analysis of effects of long-term exercise on BMI of Chinese patient with NAFLD.

Figure 6

Figure 6

Meta-analysis of effects of long-term exercise on TG of Chinese patient with NAFLD.

Figure 7

Figure 7

Meta-analysis of effects of long-term exercise on TC of Chinese patient with NAFLD.

Figure 8

Figure 8

Meta-analysis of effects of long-term exercise on LDL-C of Chinese patient with NAFLD.

Figure 9

Figure 9

Meta-analysis of effects of long-term exercise on HDL-C of Chinese patient with NAFLD.

Figure 10

Figure 10

Meta-analysis of effects of long-term exercise on ALT of Chinese patient with NAFLD.

Figure 11

Figure 11

Meta-analysis of effects of long-term exercise on AST of Chinese patient with NAFLD.

References

    1. Bianchi A., Marchetti L., Hall Z., Lemos H., Vacca M., Paish H., et al. (2021). Moderate exercise inhibits age-related inflammation, liver steatosis, senescence, and tumorigenesis. J. Immunol. 206, 904–916. 10.4049/jimmunol.2001022 - DOI - PMC - PubMed
    1. Bilet L., Brouwers B., van Ewijk P. A., Hesselink M. K. C., Kooi M. E., Schrauwen P., et al. (2015). Acute exercise does not decrease liver fat in men with overweight or NAFLD. Sci. Rep. 5, 9709. 10.1038/srep09709 - DOI - PMC - PubMed
    1. Boesch C., Slotboom J., Hoppeler H., Kreis R. (2010). In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn. Reson. Med. 37, 484–493. 10.1002/mrm.1910370403 - DOI - PubMed
    1. Byrne C. D., Targher G. (2015). NAFLD: a multisystem disease. J. Hepatol. 62, S47–S64. 10.1016/j.jhep.2014.12.012 - DOI - PubMed
    1. Caspersen C. J., Powell K. E., Christenson G. M. (1985). Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 100, 126–131. - PMC - PubMed

Publication types

LinkOut - more resources