Assignment of the gene for adrenal P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase) to human chromosome 10 - PubMed (original) (raw)
Assignment of the gene for adrenal P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase) to human chromosome 10
K J Matteson et al. J Clin Endocrinol Metab. 1986 Sep.
Abstract
P450c17 is the single enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities. We identified several human P450c17 cDNA clones in a human adrenal cDNA library we constructed in lambda gt10. A short clone containing the 3'-terminal 650 bases of the full-length sequence was used to examine Southern blots of DNA from normal persons and from a panel of mouse/human somatic cell hybrid lines. The pattern of hybridization of this cDNA to normal human DNA cut with 8 restriction endonucleases suggests the human genome has two (or more) P450c17 genes. The pattern of hybridization to the somatic cell hybrid cell lines, each containing a limited, known number of human chromosomes, indicates the human adrenal P450c17 gene lies on chromosome 10. The chromosomal locations of the other P450c17 genes could not be determined.
Similar articles
- Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues.
Chung BC, Picado-Leonard J, Haniu M, Bienkowski M, Hall PF, Shively JE, Miller WL. Chung BC, et al. Proc Natl Acad Sci U S A. 1987 Jan;84(2):407-11. doi: 10.1073/pnas.84.2.407. Proc Natl Acad Sci U S A. 1987. PMID: 3025870 Free PMC article. - Hormonal regulation of messenger ribonucleic acids for P450scc (cholesterol side-chain cleavage enzyme) and P450c17 (17 alpha-hydroxylase/17,20-lyase) in cultured human fetal adrenal cells.
Di Blasio AM, Voutilainen R, Jaffe RB, Miller WL. Di Blasio AM, et al. J Clin Endocrinol Metab. 1987 Jul;65(1):170-5. doi: 10.1210/jcem-65-1-170. J Clin Endocrinol Metab. 1987. PMID: 3034954 - Structure of genes encoding steroidogenic enzymes.
Miller WL. Miller WL. J Steroid Biochem. 1987;27(4-6):759-66. doi: 10.1016/0022-4731(87)90147-6. J Steroid Biochem. 1987. PMID: 3320556 Review. - 17 alpha-Hydroxylase/17,20-lyase defects.
Yanase T. Yanase T. J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):153-7. doi: 10.1016/0960-0760(95)00029-y. J Steroid Biochem Mol Biol. 1995. PMID: 7626447 Review.
Cited by
- Effect of Essential Oil Components on the Activity of Steroidogenic Cytochrome P450.
Sharma K, Lanzilotto A, Yakubu J, Therkelsen S, Vöegel CD, Du Toit T, Jørgensen FS, Pandey AV. Sharma K, et al. Biomolecules. 2024 Feb 8;14(2):203. doi: 10.3390/biom14020203. Biomolecules. 2024. PMID: 38397440 Free PMC article. - Case report: 17α- hydroxylase deficiency due to a hotspot variant and a novel compound heterozygous variant in the _CYP_17_A_1 gene of five Chinese patients.
Li J, Zhang Q, Chen J, Fu X, Yang J, Liu L. Li J, et al. Front Pediatr. 2022 Sep 21;10:935191. doi: 10.3389/fped.2022.935191. eCollection 2022. Front Pediatr. 2022. PMID: 36210947 Free PMC article. - 17 alpha-hydroxylase deficiency: A case report of young Chinese woman with a rare gene mutation.
Han LH, Wang L, Wu XY. Han LH, et al. Clin Case Rep. 2022 Jul 25;10(7):e6109. doi: 10.1002/ccr3.6109. eCollection 2022 Jul. Clin Case Rep. 2022. PMID: 35898732 Free PMC article. - The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis.
Chaudhary H, Patel J, Jain NK, Joshi R. Chaudhary H, et al. J Ovarian Res. 2021 Sep 26;14(1):125. doi: 10.1186/s13048-021-00879-w. J Ovarian Res. 2021. PMID: 34563259 Free PMC article. Review. - 17α-hydroxylase/17,20 carbon chain lyase deficiency caused by p.Tyr329fs homozygous mutation: Three case reports.
Zhang D, Sun JR, Xu J, Xing Y, Zheng M, Ye SD, Zhu J. Zhang D, et al. World J Clin Cases. 2021 Mar 16;9(8):1923-1930. doi: 10.12998/wjcc.v9.i8.1923. World J Clin Cases. 2021. PMID: 33748243 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases