Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production - PubMed (original) (raw)

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production

T Hirano et al. Proc Natl Acad Sci U S A. 1987 Jan.

Abstract

The partial amino acid sequence of the NH2 terminus of a factor named human B-cell differentiation factor or B-cell stimulatory factor 2 (BSF-2) has been determined. Antibodies raised against the synthetic peptide corresponding to residues 1-13 of the NH2-terminal sequence specifically react with BSF-2 generated by a T-cell line and by phytohemagglutinin-stimulated normal T cells. Furthermore, the antipeptide antibodies react with a BSF-2-like factor produced by cardiac myxoma as well as uterine cervical carcinoma cells. The results show that BSF-2 functions in vivo as well and suggest that the constitutive production of BSF-2 may be involved in autoantibody production, since patients with cardiac myxoma and uterine carcinoma showed autoantibody production.

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References

1. 1. Mayo Clin Proc. 1980 Jun;55(6):371-6 - PubMed
2. 1. Annu Rev Immunol. 1983;1:307-33 - PubMed
3. 1. J Immunol. 1981 Aug;127(2):412-6 - PubMed
4. 1. J Biol Chem. 1981 Aug 10;256(15):7990-7 - PubMed
5. 1. J Exp Med. 1981 Nov 1;154(5):1681-93 - PubMed

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