Ascorbic acid intake is inversely associated with prevalence of depressive symptoms in US midlife women: A cross-sectional study - PubMed (original) (raw)

. 2022 Feb 15:299:498-503.

doi: 10.1016/j.jad.2021.12.049. Epub 2021 Dec 21.

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Ascorbic acid intake is inversely associated with prevalence of depressive symptoms in US midlife women: A cross-sectional study

Di Li et al. J Affect Disord. 2022.

Abstract

Background: With the endocrine changes in menopausal transition period, associations between dietary ascorbic acid intake and depressive symptoms may be different. This investigation examined cross-sectional relations between dietary ascorbic acid intake of women and prevalence of depressive symptoms.

Methods: This is a secondary analysis performed on a subsample of the Study of Women's Health Across the Nation (SWAN). Women enrolled had measures of CES-D depression scores and ascorbic acid intake. Regression models were used to study cross-sectional associations between ascorbic acid intake and depressive symptoms.

Results: A total of 3088 women aged 42-52 years at baseline were included in the present study. Dietary ascorbic acid intake was inversely associated with depressive symptoms. The adjusted OR and 95% CI of depressive symptoms was 0.699 (0.524 - 0.934) in quartile 4 (the highest) versus quartile 1 (the lowest) of the ascorbic acid intake. Restricted cubic spline analyze showed a suggestion of L-shaped associations between ascorbic acid intake and depressive symptoms.

Conclusions: Ascorbic acid intake is inversely associated with prevalence of depressive symptoms in midlife women. Future prospective cohort studies are needed to confirm these findings.

Keywords: Ascorbic acid; Depressive symptoms; Epidemiology; Midlife women.

Copyright © 2021. Published by Elsevier B.V.

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