The dynamics of free calcium in dendritic spines in response to repetitive synaptic input - PubMed (original) (raw)
The dynamics of free calcium in dendritic spines in response to repetitive synaptic input
E Gamble et al. Science. 1987.
Abstract
Increased levels of intracellular calcium at either pre- or postsynaptic sites are thought to precede changes in synaptic strength. Thus, to induce long-term potentiation in the hippocampus, periods of intense synaptic stimulation would have to transiently raise the levels of cytosolic calcium at postsynaptic sites--dendritic spines in the majority of cases. Since direct experimental verification of this hypothesis is not possible at present, calcium levels have been studied by numerically solving the appropriate electro-diffusion equations for two different postsynaptic structures. Under the assumption that voltage-dependent calcium channels are present on dendritic spines, free intracellular calcium in spines can reach micromolar levels after as few as seven spikes in 20 milliseconds. Moreover, a short, but high-frequency, burst of presynaptic activity is more effective in raising levels of calcium and especially of the calcium-calmodulin complex than sustained low-frequency activity. This behavior is different from that seen at the soma of a typical vertebrate neuron.
Similar articles
- A model of NMDA receptor-mediated activity in dendrites of hippocampal CA1 pyramidal neurons.
Pongrácz F, Poolos NP, Kocsis JD, Shepherd GM. Pongrácz F, et al. J Neurophysiol. 1992 Dec;68(6):2248-59. doi: 10.1152/jn.1992.68.6.2248. J Neurophysiol. 1992. PMID: 1337105 Free PMC article. - NMDA receptors amplify calcium influx into dendritic spines during associative pre- and postsynaptic activation.
Schiller J, Schiller Y, Clapham DE. Schiller J, et al. Nat Neurosci. 1998 Jun;1(2):114-8. doi: 10.1038/363. Nat Neurosci. 1998. PMID: 10195125 - Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala.
Humeau Y, Lüthi A. Humeau Y, et al. Neuropharmacology. 2007 Jan;52(1):234-43. doi: 10.1016/j.neuropharm.2006.07.010. Epub 2006 Aug 4. Neuropharmacology. 2007. PMID: 16890250 - Calcium dynamics in spines: link to synaptic plasticity.
Holthoff K, Tsay D. Holthoff K, et al. Exp Physiol. 2002 Nov;87(6):725-31. doi: 10.1113/eph8702463. Exp Physiol. 2002. PMID: 12530404 Review. - Active dendrites, potassium channels and synaptic plasticity.
Johnston D, Christie BR, Frick A, Gray R, Hoffman DA, Schexnayder LK, Watanabe S, Yuan LL. Johnston D, et al. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):667-74. doi: 10.1098/rstb.2002.1248. Philos Trans R Soc Lond B Biol Sci. 2003. PMID: 12740112 Free PMC article. Review.
Cited by
- Competitive processes shape multi-synapse plasticity along dendritic segments.
Chater TE, Eggl MF, Goda Y, Tchumatchenko T. Chater TE, et al. Nat Commun. 2024 Aug 31;15(1):7572. doi: 10.1038/s41467-024-51919-0. Nat Commun. 2024. PMID: 39217140 Free PMC article. - Electrical recordings from dendritic spines of adult mouse hippocampus and effect of the actin cytoskeleton.
Priel A, Dai XQ, Chen XZ, Scarinci N, Cantero MDR, Cantiello HF. Priel A, et al. Front Mol Neurosci. 2022 Aug 25;15:769725. doi: 10.3389/fnmol.2022.769725. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36090255 Free PMC article. - Endocytosis of Connexin 36 is Mediated by Interaction with Caveolin-1.
Kotova A, Timonina K, Zoidl GR. Kotova A, et al. Int J Mol Sci. 2020 Jul 29;21(15):5401. doi: 10.3390/ijms21155401. Int J Mol Sci. 2020. PMID: 32751343 Free PMC article. - General differential Hebbian learning: Capturing temporal relations between events in neural networks and the brain.
Zappacosta S, Mannella F, Mirolli M, Baldassarre G. Zappacosta S, et al. PLoS Comput Biol. 2018 Aug 28;14(8):e1006227. doi: 10.1371/journal.pcbi.1006227. eCollection 2018 Aug. PLoS Comput Biol. 2018. PMID: 30153263 Free PMC article. - LTP or LTD? Modeling the Influence of Stress on Synaptic Plasticity.
Peters A, Reisch C, Langemann D. Peters A, et al. eNeuro. 2018 Apr 6;5(1):ENEURO.0242-17.2018. doi: 10.1523/ENEURO.0242-17.2018. eCollection 2018 Jan-Feb. eNeuro. 2018. PMID: 29662939 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources