Ontogeny and tissue distribution of the chicken Bu-1a antigen - PubMed (original) (raw)

Ontogeny and tissue distribution of the chicken Bu-1a antigen

E Houssaint et al. Immunology. 1987 Nov.

Abstract

By using a sensitive technique of immunofluorescence on polyethylene glycol-embedded tissue sections, we could better determine the distribution of L22+ cells in embryonic and adult chickens. L22 mAb was originally described as reacting with bursa and bursa-derived lymphocytes. We now present evidence to suggest that this mAb also reacts with a subset of macrophages found in bursa, thymus, spleen, liver, intestine and peritoneum. The L22+ cells appear early during embryonic life, simultaneously in yolk sac, bursa, thymus, spleen and bone marrow. At all steps of their ontogeny, thymocytes were L22-, while most, if not all, bursal lymphoid cells were L22+. Moreover, L22 antigen can be detected on haemopoietic cells probably precursors, before and during their entry into the bursal rudiment on Day 9 or 10 of embryonic life. We conclude from these data that L22 is not restricted to the B-cell lineage as it is shared with a subset of macrophages. Furthermore, our observations of L22+ cells during embryonic life favour the hypothesis of separate lineages for B-cell and T-cell precursors in chick embryo, which was previously put forward on the basis of different sets of experiments.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Eur J Immunol. 1984 May;14(5):385-91 - PubMed
    1. J Immunol. 1984 May;132(5):2524-30 - PubMed
    1. Eur J Immunol. 1984 Sep;14(9):831-9 - PubMed
    1. J Exp Med. 1984 Dec 1;160(6):1803-19 - PubMed
    1. Eur J Immunol. 1985 Jan;15(1):83-7 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources