The effect of vitamin B12-supplementation on actigraphy measured sleep pattern; a randomized control trial - PubMed (original) (raw)
Randomized Controlled Trial
. 2022 Feb;41(2):307-312.
doi: 10.1016/j.clnu.2021.11.040. Epub 2021 Dec 6.
Affiliations
- PMID: 34999324
- DOI: 10.1016/j.clnu.2021.11.040
Free article
Randomized Controlled Trial
The effect of vitamin B12-supplementation on actigraphy measured sleep pattern; a randomized control trial
Mari Hysing et al. Clin Nutr. 2022 Feb.
Free article
Abstract
Background: Vitamin B12 deficiency is common worldwide and has been associated with poor sleep. The effect of vitamin B12 supplementation on sleep in infants is not known.
Aims: To measure the effect of daily supplementation of vitamin B12 for one year on sleep in infants at risk of deficiency.
Methods: This was an individually randomized double-blind placebo-controlled trial in 600 infants in low-to middle-income neighborhoods in Bhaktapur, Nepal of daily supplementation of vitamin B12 for one year. Infants were included if they were 6-11 month year-old and with a length-for-age less than one z-score. Sleep was a predefined, secondary outcome, and was measured by actigraphy including sleep duration at night and total sleep duration (day and night), sleep onset latency (SOL), and wake after sleep onset (WASO). The effect of vitamin B12 on sleep was additionally assessed in predefined subgroups defined by stunting, underweight, vitamin B12 status, low birthweight, anemia and exclusive breastfeeding for 3 months.
Results: There was no effect of vitamin B12 supplementation on sleep duration at night, total sleep duration, or WASO. There was a small significant negative effect for SOL. None of the included subgroup analyses revealed effect modification on any of the sleep outcomes.
Conclusion: Overall, vitamin B12 supplementation did not have an effect on sleep in infants or for high-risk subgroups, with the exception of a small negative effect for SOL. The present study does not support vitamin B12 supplementation to improve sleep in infants.
Trial registration: clinicaltrials.gov: NCT02272842.
Universal trial number: U1111-1161-5187.
Keywords: B12 supplementation; Infant sleep; Randomized controlled trial; Sleep duration.
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Conflict of interest None reported.
Similar articles
- Effects of vitamin B12 supplementation on neurodevelopment and growth in Nepalese Infants: A randomized controlled trial.
Strand TA, Ulak M, Hysing M, Ranjitkar S, Kvestad I, Shrestha M, Ueland PM, McCann A, Shrestha PS, Shrestha LS, Chandyo RK. Strand TA, et al. PLoS Med. 2020 Dec 1;17(12):e1003430. doi: 10.1371/journal.pmed.1003430. eCollection 2020 Dec. PLoS Med. 2020. PMID: 33259482 Free PMC article. Clinical Trial. - The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial.
Strand TA, Ulak M, Chandyo RK, Kvestad I, Hysing M, Shrestha M, Basnet S, Ranjitkar S, Shrestha L, Shrestha PS. Strand TA, et al. Trials. 2017 Apr 21;18(1):187. doi: 10.1186/s13063-017-1937-0. Trials. 2017. PMID: 28431557 Free PMC article. Clinical Trial. - The Effect of Vitamin B12 Supplementation on Leukocyte Telomere Length in Mildly Stunted Nepalese Children: A Secondary Outcome of a Randomized Controlled Trial.
Ulak M, Kvestad I, Chandyo RK, Schwinger C, Basnet S, Shrestha M, Ranjitkar S, Nguyen LV, Corona-Pérez D, De Vivo I, Ueland PM, McCann A, Strand TA. Ulak M, et al. J Nutr. 2024 Aug;154(8):2543-2550. doi: 10.1016/j.tjnut.2023.10.015. Epub 2023 Oct 31. J Nutr. 2024. PMID: 37918674 Clinical Trial. - Folic acid with or without vitamin B12 for cognition and dementia.
Malouf M, Grimley EJ, Areosa SA. Malouf M, et al. Cochrane Database Syst Rev. 2003;(4):CD004514. doi: 10.1002/14651858.CD004514. Cochrane Database Syst Rev. 2003. PMID: 14584018 Updated. Review. - Folic acid with or without vitamin B12 for the prevention and treatment of healthy elderly and demented people.
Malouf R, Grimley Evans J. Malouf R, et al. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004514. doi: 10.1002/14651858.CD004514.pub2. Cochrane Database Syst Rev. 2008. PMID: 18843658 Review.
Cited by
- Sleep disorder, Mediterranean diet, and all-cause and cause-specific mortality: a prospective cohort study.
Wang Y, Fan H, Ren Z, Liu X, Niu X. Wang Y, et al. BMC Public Health. 2023 May 18;23(1):904. doi: 10.1186/s12889-023-15870-x. BMC Public Health. 2023. PMID: 37202744 Free PMC article. - Colic and sleep outcomes of nonpharmacological intervention in infants with infantile colic: systematic review and metaanalysis.
Tanrıverdi DÇ, Karaahmet AY, Bilgiç FŞ. Tanrıverdi DÇ, et al. Rev Assoc Med Bras (1992). 2023 May 19;69(5):e20230071. doi: 10.1590/1806-9282.20230071. eCollection 2023. Rev Assoc Med Bras (1992). 2023. PMID: 37222334 Free PMC article. - Vitamin B12 status in infancy and the effect of a vitamin B12 injection in infants with subclinical vitamin B12 deficiency: study protocol for a register-based randomised controlled trial.
Bakken KS, Kvestad I, Bjørkevoll SMG, Solvik BS, Kaldenbach S, McCann A, Holten-Andersen MN, Ersvær E, Konijnenberg C, Strand TA. Bakken KS, et al. BMJ Open. 2023 Apr 20;13(4):e069102. doi: 10.1136/bmjopen-2022-069102. BMJ Open. 2023. PMID: 37080624 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical