Lymphotoxin is an important T cell-derived growth factor for human B cells - PubMed (original) (raw)
. 1987 Nov 20;238(4830):1144-6.
doi: 10.1126/science.3500512.
Affiliations
- PMID: 3500512
- DOI: 10.1126/science.3500512
Lymphotoxin is an important T cell-derived growth factor for human B cells
J H Kehrl et al. Science. 1987.
Abstract
Two different assays for B cell growth factors (BCGF) and an antibody against lymphotoxin were used to show that the presence of lymphotoxin in conditioned media derived from normal activated T cells and in a partially purified BCGF accounts for a substantial portion of their B cell growth-promoting activity. A competitive binding assay confirmed the presence of significant amounts of lymphotoxin in the partially purified BCGF. Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2.
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