The effects of oral magnesium supplementation on glycaemic control in patients with type 2 diabetes: a systematic review and dose-response meta-analysis of controlled clinical trials - PubMed (original) (raw)

Meta-Analysis

. 2022 Dec 28;128(12):2363-2372.

doi: 10.1017/S0007114521005201. Epub 2022 Jan 20.

Affiliations

• PMID: 35045911
• DOI: 10.1017/S0007114521005201

Meta-Analysis

The effects of oral magnesium supplementation on glycaemic control in patients with type 2 diabetes: a systematic review and dose-response meta-analysis of controlled clinical trials

Omid Asbaghi et al. Br J Nutr. 2022.

Abstract

The current systematic review and meta-analysis were conducted to evaluate the effects of oral Mg supplementation on glycaemic control in type 2 diabetes mellitus (T2DM) patients. Related articles were found by searching the PubMed, SCOPUS, Embase and Web of Science databases (from inception to 30 February 2020). A one-stage robust error meta-regression model based on inverse variance weighted least squares regression and cluster robust error variances was used for the dose-response analysis between Mg supplementation and duration of intervention and glycaemic control factors. Eighteen eligible randomised clinical trials were included in our final analysis. The dose-response testing indicated that the estimated mean difference in HbA1c at 500 mg/d was -0·73 % (95 % CI: -1·25, -0·22) suggesting modest improvement in HbA1c with strong evidence (P value: 0·004). And in fasting blood sugar (FBS) at 360 mg/d was -7·11 mg/dl (95 % CI: -14·03, -0·19) suggesting minimal amelioration in FBS with weak evidence (P value: 0·092) against the model hypothesis at this sample size. The estimated mean difference in FBS and HbA1c at 24 weeks was -15·58 mg/dl (95 % CI: -24·67, -6·49) and -0·48 (95 % CI: -0·77, -0·19), respectively, suggesting modest improvement in FBS (P value: 0·034) and HbA1c (P value: 0·001) with strong evidence against the model hypothesis at this sample size. Oral Mg supplementation could have an effect on glycaemic control in T2DM patients. However, the clinical trials so far are not sufficient to make guidelines for clinical practice.

Keywords: Glycaemic control; Magnesium supplementation; Meta-analysis; Type 2 diabetes.

PubMed Disclaimer

Similar articles

• The Effect of Vitamin D Supplementation on Glycemic Control and Cardiovascular Risk Factors in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis of Clinical Trials.
  Afraie M, Bahrami P, Kohnepoushi P, Khateri S, Majidi L, Saed L, Zamani K, Baharm HM, Moradi Y, Moradpour F. Afraie M, et al. J Diabetes Res. 2024 Sep 10;2024:9960656. doi: 10.1155/2024/9960656. eCollection 2024. J Diabetes Res. 2024. PMID: 39290798 Free PMC article.
• Folic Acid Supplementation Improves Glycemic Control for Diabetes Prevention and Management: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.
  Asbaghi O, Ashtary-Larky D, Bagheri R, Moosavian SP, Olyaei HP, Nazarian B, Rezaei Kelishadi M, Wong A, Candow DG, Dutheil F, Suzuki K, Alavi Naeini A. Asbaghi O, et al. Nutrients. 2021 Jul 9;13(7):2355. doi: 10.3390/nu13072355. Nutrients. 2021. PMID: 34371867 Free PMC article.
• The effect of oral supplementation of ginger on glycemic control of patients with type 2 diabetes mellitus - A systematic review and meta-analysis.
  Schumacher JC, Mueller V, Sousa C, Peres KK, da Mata IR, Menezes RCR, Dal Bosco SM. Schumacher JC, et al. Clin Nutr ESPEN. 2024 Oct;63:615-622. doi: 10.1016/j.clnesp.2024.07.011. Epub 2024 Jul 23. Clin Nutr ESPEN. 2024. PMID: 39053695
• The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis.
  Ziaei R, Foshati S, Hadi A, Kermani MAH, Ghavami A, Clark CCT, Tarrahi MJ. Ziaei R, et al. Phytother Res. 2020 Feb;34(2):282-294. doi: 10.1002/ptr.6535. Epub 2019 Dec 4. Phytother Res. 2020. PMID: 31802554
• Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
  Asbaghi O, Fatemeh N, Mahnaz RK, Ehsan G, Elham E, Behzad N, Damoon AL, Amirmansour AN. Asbaghi O, et al. Pharmacol Res. 2020 Nov;161:105098. doi: 10.1016/j.phrs.2020.105098. Epub 2020 Jul 28. Pharmacol Res. 2020. PMID: 32730903

Cited by

• A Reflection of Metabolic Syndrome through the Window of COVID-19.
  Ho LP, Tan CW, Ng HJ, Jason Chay WM, Tan JY, Goh SY. Ho LP, et al. Vaccines (Basel). 2022 Nov 19;10(11):1966. doi: 10.3390/vaccines10111966. Vaccines (Basel). 2022. PMID: 36423061 Free PMC article.
• Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes.
  Wang F, Mao Y, Sun J, Yang J, Xiao L, Huang Q, Wei C, Gou Z, Zhang K. Wang F, et al. Sci Rep. 2025 Feb 7;15(1):4600. doi: 10.1038/s41598-025-88480-9. Sci Rep. 2025. PMID: 39920222 Free PMC article.
• Relationship between serum magnesium levels and glycemic control and insulin resistance.
  Erinc O, Yesilyurt S. Erinc O, et al. North Clin Istanb. 2025 Apr 25;12(2):239-243. doi: 10.14744/nci.2024.75725. eCollection 2025. North Clin Istanb. 2025. PMID: 40330523 Free PMC article.
• The Association of Serum and Dietary Magnesium with Depressive Symptoms.
  Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Chou MH, et al. Nutrients. 2023 Feb 2;15(3):774. doi: 10.3390/nu15030774. Nutrients. 2023. PMID: 36771478 Free PMC article.
• The Effects of Magnesium Supplementation on Serum Magnesium and Calcium Concentration in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
  Zamani M, Haghighat N. Zamani M, et al. Clin Nutr Res. 2022 Apr 29;11(2):133-145. doi: 10.7762/cnr.2022.11.2.133. eCollection 2022 Apr. Clin Nutr Res. 2022. PMID: 35559000 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Cambridge University Press
  • Ovid Technologies, Inc.

• Medical

  • MedlinePlus Health Information