Global molecular epidemiology of microsporidia in pigs and wild boars with emphasis on Enterocytozoon bieneusi: A systematic review and meta-analysis - PubMed (original) (raw)

Meta-Analysis

. 2022 May;8(3):1126-1136.

doi: 10.1002/vms3.751. Epub 2022 Feb 3.

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Meta-Analysis

Global molecular epidemiology of microsporidia in pigs and wild boars with emphasis on Enterocytozoon bieneusi: A systematic review and meta-analysis

Ali Taghipour et al. Vet Med Sci. 2022 May.

Abstract

Background: Microsporidia are spore-forming intracellular pathogens with worldwide prevalence, causing emerging infections in humans and animals. Enterocytozoon bieneusi is a zoonotic species of microsporidia and is responsible for more than 90% of cases of microsporidiosis in humans and animals. Pigs and wild boars are important animal reservoirs of microsporidia. Hence, we aimed to estimate the global prevalence of microsporidia and genetic diversity of E. bieneusi in pigs and wild boars through a set of systematic review and meta-analysis (PRISMA) guidelines.

Methods: Four databases (Web of Science, PubMed, Scopus and Google Scholar) were searched between January 1, 2000 and April 30, 2021. Regarding meta-analysis, the random-effect model was employed by forest plot with 95% confidence interval (CI).

Results: After exclusion of irrelevant articles and duplication removal, 33 papers, including 34 datasets (30 datasets for domestic pigs and 4 for wild boars) finally meet the inclusion criteria to undergo meta-analysis. The pooled prevalence rates of microsporidia infection in domestic pigs and wild boars were 37.6% (95% CI: 30.8-44.9%) and 8.1% (95% CI: 2.1-26.8%), respectively. While, the pooled prevalence rates of E. bieneusi were 35% (95% CI: 28.4-42.2%) in domestic pigs and 10.1% (95% CI: 1.7-42.4%) in wild boars. The genotypes EbpA was the most reported genotype in domestic pigs and wild boars. Male animals had higher prevalence rates of microsporidia infection than females (27 vs. 17.4%, OR = 1.91; 95% CI, 0.77-4.71%).

Conclusion: This study indicates the important role of domestic pigs and wild boars as animal reservoir hosts of microsporidia. Thereby, strategies for control and prevention of these zoonotic pathogens should be designed in pigs and wild boars.

Keywords: Enterocytozoon bieneusi; domestic pig; microsporidia; systematic review; wild boar.

© 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd.

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Conflict of interest statement

The authors declare no conflict of interest..

Figures

FIGURE 1

FIGURE 1

PRISMA flow diagram describing included or excluded studies

FIGURE 2

FIGURE 2

The pooled molecular prevalence of E. bieneusi infection in domestic pigs

FIGURE 3

FIGURE 3

The pooled molecular prevalence of E. bieneusi infection in wild boars

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