L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen - PubMed (original) (raw)

. 1986 Feb;122(2):199-203.

• PMID: 3511719
• PMCID: PMC1888104

L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen

S M Hsu et al. Am J Pathol. 1986 Feb.

Abstract

Anti-Leu M1 generally does not stain the lymphocytic and histiocytic (L&H) variants of Reed-Sternberg cells in the lymphocyte predominant type of Hodgkin's disease. However, the authors found that after neuraminidase treatment for removal of sialic acid, the L&H cells in more than half of the cases studied could be stained by anti-Leu M1. This result strongly suggests that L&H cells differ from the Reed-Sternberg cells in other types of Hodgkin's disease in their unique capacity to sialylate the 150-kd Leu M1 antigen.

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