HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis - PubMed (original) (raw)
Meta-Analysis
. 2022 Jul;77(1):128-139.
doi: 10.1016/j.jhep.2022.01.023. Epub 2022 Feb 6.
Emily Zhang 2, Manasa Narasimman 2, Nicole E Rich 2, Akbar K Waljee 3, Yujin Hoshida 2, Ju Dong Yang 4, Maria Reig 5, Giuseppe Cabibbo 6, Pierre Nahon 7, Neehar D Parikh 3, Jorge A Marrero 8
Affiliations
- PMID: 35139400
- PMCID: PMC9232881
- DOI: 10.1016/j.jhep.2022.01.023
Meta-Analysis
HCC surveillance improves early detection, curative treatment receipt, and survival in patients with cirrhosis: A meta-analysis
Amit G Singal et al. J Hepatol. 2022 Jul.
Abstract
Background & aims: There is controversy regarding the overall value of hepatocellular carcinoma (HCC) surveillance in patients with cirrhosis given the lack of data from randomized-controlled trials. To address this issue, we conducted a systematic review and meta-analysis of cohort studies evaluating the benefits and harms of HCC surveillance in patients with cirrhosis.
Methods: We performed a search of the Medline and EMBASE databases and national meeting abstracts from January 2014 through July 2020 for studies reporting early-stage HCC detection, curative treatment receipt, or overall survival, stratified by HCC surveillance status, among patients with cirrhosis. Pooled risk ratios (RRs) and hazard ratios, according to HCC surveillance status, were calculated for each outcome using the DerSimonian and Laird method for random effects models.
Results: We identified 59 studies including 145,396 patients with HCC, which was detected by surveillance in 41,052 (28.2%) cases. HCC surveillance was associated with improved early-stage detection (RR 1.86, 95% CI 1.73-1.98; I2 = 82%), curative treatment receipt (RR 1.83, 95% CI 1.69-1.97; I2 = 75%), and overall survival (hazard ratio 0.67, 95% CI 0.61-0.72; I2 = 78%) after adjusting for lead-time bias; however, there was notable heterogeneity in all pooled estimates. Four studies examined surveillance-related physical harms due to false positive or indeterminate surveillance results, but no studies examined potential financial or psychological harms. The proportion of patients experiencing surveillance-related physical harms ranged from 8.8% to 27.5% across studies, although most harms were mild in severity.
Conclusion: HCC surveillance is associated with improved early detection, curative treatment receipt, and survival in patients with cirrhosis, although there was heterogeneity in pooled estimates. Available data suggest HCC surveillance is of high value in patients with cirrhosis, although continued rigorous studies evaluating benefits and harms are still needed.
Lay summary: There has been ongoing debate about the overall value of hepatocellular carcinoma (HCC) screening in patients with cirrhosis given the lack of data from randomized-controlled trials. In a systematic review of contemporary cohort studies, we found that HCC screening is associated with improved early detection, curative treatment receipt, and survival in patients with cirrhosis, although there were fewer data quantifying potential screening-related harms. Available data suggest HCC screening is of high value in patients with cirrhosis, although continued studies evaluating benefits and harms are still needed.
Keywords: Screening; cirrhosis; early detection; liver cancer; ultrasound.
Copyright © 2022 European Association for the Study of the Liver. All rights reserved.
Conflict of interest statement
Conflict of Interest Amit Singal has served as a consultant or on advisory boards for Bayer, Wako Diagnostics, Exact Sciences, Roche, Glycotest, and GRAIL. Jorge Marrero has served as a consultant for Glycotest. Neehar Parikh has served as a consultant or on advisory boards for Bayer, Wako Diagnostics, Exact Sciences, Glycotest, and Freenome. Maria Reig has served as consulant or advisory boards for Bayer-Shering Pharma, BMS, Roche, Ipsen, AstraZeneca, Lilly, BTG/Paid conferences: Bayer-Shering Pharma, BMS, Gilead, Lilly and is a principal investigator of research Grants of Bayer-Shering Pharma, Ipsen. Giuseppe Cabibbo has served as a consultant or on advisory boards for Bayer, Eisai, and Ipsen. Ju Dong Yang has served as a consultant or on advisory boards for Exact Sciences and Gilead Sciences and Eisai. None of the other authors have any relevant conflicts of interest. Please refer to the accompanying ICMJE disclosure forms for further details.
Figures
Figure 1.. Association Between HCC Surveillance and Early Tumor Detection
Patients who underwent surveillance were significantly more likely to have HCC diagnosed at an early stage (OR 1.94, 95% CI 1.80 – 2.08); however, there was significant heterogeneity (I2=84%, p<0.001). DerSimonian and Laird method was used for a random effects model.
Figure 2.. Association Between HCC Surveillance and Curative Treatment Receipt
Patients diagnosed by surveillance were significantly more likely to undergo curative therapy, with a pooled odds ratio of 1.83 (95%CI 1.69 – 1.97), although there was high heterogeneity among studies (I2=75%, p<0.001). DerSimonian and Laird method was used for a random effects model.
Figure 3.. Association Between HCC Surveillance and Overall Survival
HCC surveillance was significantly associated with improved survival, with a pooled hazard ratio of 0.66 (95%CI 0.61 – 0.71); however, there was high heterogeneity (I2=75%, p<0.001). DerSimonian and Laird method was used for a random effects model.
Comment in
- HCC prediction post SVR: Many tools yet limited generalizability!
Bhagat N, Verma N, Singh V. Bhagat N, et al. J Hepatol. 2022 Oct;77(4):1226-1228. doi: 10.1016/j.jhep.2022.04.028. Epub 2022 May 5. J Hepatol. 2022. PMID: 35526784 No abstract available. - Reply to: "HCC prediction post SVR: many tools yet limited generalizability!": De novo HCC risk stratification after HCV cure: All roads lead to Rome?
Semmler G, Meyer EL, Mandorfer M. Semmler G, et al. J Hepatol. 2022 Oct;77(4):1228-1230. doi: 10.1016/j.jhep.2022.07.011. Epub 2022 Jul 20. J Hepatol. 2022. PMID: 35868585 No abstract available. - Correction for length bias reduces the mortality benefit from hepatocellular carcinoma surveillance.
Robins CJG, Buchanan RM. Robins CJG, et al. J Hepatol. 2023 Aug;79(2):e88-e90. doi: 10.1016/j.jhep.2023.02.016. Epub 2023 Feb 21. J Hepatol. 2023. PMID: 36822478 No abstract available. - Reply to: "Correction for length bias reduces the mortality benefit from hepatocellular carcinoma surveillance".
Singal AG, Marrero J, Parikh ND. Singal AG, et al. J Hepatol. 2023 Aug;79(2):e90-e92. doi: 10.1016/j.jhep.2023.05.008. Epub 2023 May 16. J Hepatol. 2023. PMID: 37201671 No abstract available.
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