Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria - PubMed (original) (raw)
Comparative Study
Increased transcapillary escape rate of albumin in type 1 (insulin-dependent) diabetic patients with microalbuminuria
B Feldt-Rasmussen. Diabetologia. 1986 May.
Abstract
The transcapillary escape rate, intravascular mass and outflux of albumin were measured in 75 Type 1 (insulin-dependent) diabetic patients. The groups were defined as: group 1: normal urinary albumin excretion, less than 30 mg/24 h (n = 21); group 2: microalbuminuria, 30-300 mg/24 h (n = 36); group 3: diabetic nephropathy, less than 300 mg/24 h (n = 18). Fifteen sex- and age-matched non-diabetic persons served as control subjects. The diabetes duration was: group 1: 20 +/- 9 years, group 2: 17 +/- 5 years, group 3: 19 +/- 7 years. The transcapillary escape rate of albumin was similar in controls and group 1 (5.0 +/- 1.8 versus 5.2 +/- 1.5%) and was significantly higher in the microalbuminuric group 2 and group 3 (8.1 +/- 2.2 versus 8.1 +/- 2.3%). The differences were not explained by differences in metabolic control or blood pressure at the time of investigation. The outflux of albumin was also higher in group 2 than in group 1 and controls (7.1 +/- 2.0 versus 5.3 +/- 1.5 and 5.1 +/- 2.0 g/h X 1.73 m2). It was indistinguishable from controls in group 3 (5.8 +/- 1.5 g/h X 1.73 m2) because of a reduced intravascular mass of albumin (p less than 0.01) in group 3. In conclusion, a universal vascular leakage of albumin is an early event in the development of diabetic nephropathy, with the leakage of albumin being fully developed in the microalbuminuric patient. In contrast, long-term diabetic patients with normal urinary albumin excretion have a normal transcapillary escape rate of albumin.
Similar articles
- Transcapillary escape rate of albumin in hypertensive patients with type 1 (insulin-dependent) diabetes mellitus.
Nørgaard K, Jensen T, Feldt-Rasmussen B. Nørgaard K, et al. Diabetologia. 1993 Jan;36(1):57-61. doi: 10.1007/BF00399094. Diabetologia. 1993. PMID: 8436254 - Transcapillary escape rate of albumin in type II diabetic patients. The relationship with microalbuminuria and hypertension.
Nannipieri M, Penno G, Rizzo L, Pucci L, Bandinelli S, Mattei P, Taddei S, Salvetti A, Navalesi R. Nannipieri M, et al. Diabetes Care. 1997 Jun;20(6):1019-26. doi: 10.2337/diacare.20.6.1019. Diabetes Care. 1997. PMID: 9167118 - Transcapillary escape rate and albuminuria in Type II diabetes. Effects of short-term treatment with low-molecular weight heparin.
Nielsen S, Schmitz A, Bacher T, Rehling M, Ingerslev J, Mogensen CE. Nielsen S, et al. Diabetologia. 1999 Jan;42(1):60-7. doi: 10.1007/s001250051114. Diabetologia. 1999. PMID: 10027580 Clinical Trial. - Relationships among microalbuminuria, insulin resistance and renal-cardiac complications in insulin dependent and non insulin dependent diabetes.
Nosadini R, Brocco E. Nosadini R, et al. Exp Clin Endocrinol Diabetes. 1997;105 Suppl 2:1-7. doi: 10.1055/s-0029-1211783. Exp Clin Endocrinol Diabetes. 1997. PMID: 9288531 Review.
Cited by
- Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study.
Wang Y, Li F, Chu C, Zhang X, Zhang XY, Liao YY, Du MF, Zou T, Ma Q, Chen C, Wang D, Wang KK, Yan Y, Sun Y, Hu GL, Jia H, Li H, Niu ZJ, Yan RC, Man ZY, Wang L, Luo WJ, Zhang J, Li CH, Lu WH, Chang J, Safirstein R, Lu Y, Mu JJ. Wang Y, et al. EClinicalMedicine. 2022 Apr 28;48:101420. doi: 10.1016/j.eclinm.2022.101420. eCollection 2022 Jun. EClinicalMedicine. 2022. PMID: 35516445 Free PMC article. - The Aggressive Diabetic Kidney Disease in Youth-Onset Type 2 Diabetes: Pathogenetic Mechanisms and Potential Therapies.
Amatruda M, Gembillo G, Giuffrida AE, Santoro D, Conti G. Amatruda M, et al. Medicina (Kaunas). 2021 Aug 25;57(9):868. doi: 10.3390/medicina57090868. Medicina (Kaunas). 2021. PMID: 34577791 Free PMC article. Review. - Role of Albuminuria in Detecting Cardio-Renal Risk and Outcome in Diabetic Subjects.
Pafundi PC, Garofalo C, Galiero R, Borrelli S, Caturano A, Rinaldi L, Provenzano M, Salvatore T, De Nicola L, Minutolo R, Sasso FC. Pafundi PC, et al. Diagnostics (Basel). 2021 Feb 12;11(2):290. doi: 10.3390/diagnostics11020290. Diagnostics (Basel). 2021. PMID: 33673215 Free PMC article. Review. - Effects of different mean arterial pressure targets on plasma volume, ANP and glycocalyx-A randomized trial.
Damén T, Saadati S, Forssell-Aronsson E, Hesse C, Bentzer P, Ricksten SE, Nygren A. Damén T, et al. Acta Anaesthesiol Scand. 2021 Feb;65(2):220-227. doi: 10.1111/aas.13710. Epub 2020 Oct 5. Acta Anaesthesiol Scand. 2021. PMID: 32965691 Free PMC article. Clinical Trial. - Cardiac risk assessment for end-stage renal disease patients on the renal transplant waiting list.
Tabriziani H, Baron P, Abudayyeh I, Lipkowitz M. Tabriziani H, et al. Clin Kidney J. 2019 Apr 25;12(4):576-585. doi: 10.1093/ckj/sfz039. eCollection 2019 Aug. Clin Kidney J. 2019. PMID: 31384451 Free PMC article.
References
- Scand J Clin Lab Invest. 1973 Aug;32(1):81-7 - PubMed
- Clin Chim Acta. 1972 Oct;41:209-17 - PubMed
- Diabetologia. 1976 May;12(2):161-6 - PubMed
- N Engl J Med. 1984 Jul 12;311(2):89-93 - PubMed
- Hypertension. 1985 Nov-Dec;7(6 Pt 2):II18-20 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical