Dermal Duct Tumor: A Diagnostic Dilemma - PubMed (original) (raw)

Review

Dermal Duct Tumor: A Diagnostic Dilemma

Austinn C Miller et al. Dermatopathology (Basel). 2022.

Abstract

Poromas or poroid tumors are a group of rare, benign cutaneous neoplasms derived from the terminal eccrine or apocrine sweat gland duct. There are four poroma variants with overlapping features: dermal duct tumor (DDT), eccrine poroma, hidroacanthoma simplex, and poroid hidradenoma, of which DDT is the least common. Clinically, the variants have a nonspecific appearance and present as solitary dome-shaped papules, plaques, or nodules. They can be indistinguishable from each other and a multitude of differential diagnoses, necessitating a better understanding of the characteristics that make the diagnosis of poroid neoplasms. However, there remains a paucity of information on these lesions, especially DDTs, given their infrequent occurrence. Herein, we review the literature on DDTs with an emphasis on epidemiology, pathogenesis, clinical features, diagnosis, and management.

Keywords: DDT; dermal duct tumor; hidradenoma; poroid; poroma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

A simplified schematic of keratin expression in an eccrine sweat gland is shown [6,10]. The basal keratinocytes of the sweat duct ridge and lower intraepidermal acrosyringium are thought to give rise to poroid neoplasms based on the similarities in keratin expression [6,10]. K5 and K14 expression is ubiquitous throughout poromas, while K1 and K10 are found in focal aggregates. K77 is restricted to normal luminal cells embedded within the tumors.

Figure 2

Figure 2

Dermal duct tumor: a small, purple-brown papule at the right superior nasolabial fold.

Figure 3

Figure 3

Well circumscribed, dermal-based, solid and cystic tumor with no connection to the overlying epidermis (H & E, 2×).

Figure 4

Figure 4

Higher magnification reveals small poriod cells with round to oval nuclei and scant cytoplasm. Ductal lumen formation is present (H & E, 10×).

Figure 5

Figure 5

Residual DDT on punch excision (from the transected spiecimen in Figure 3) (H & E, 10×).

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References

    1. Sawaya J.L., Khachemoune A. Poroma: A review of eccrine, apocrine, and malignant forms. Int. J. Dermatol. 2014;53:1053–1061. doi: 10.1111/ijd.12448. - DOI - PubMed
    1. Lu R., Krathen R.A., Markus R.F. An unusual tumor of the forearm. Derm. Online J. 2006;12:13. doi: 10.5070/D33DG4W9TX. - DOI - PubMed
    1. Ahmed Jan N., Masood S. StatPearls [Internet] Statpearls Publishing; Treasure Island, FL, USA: 2021. [(accessed on 30 October 2021)]. Poroma. Available online: http://www.ncbi.nlm.nih.gov/books/NBK560909/
    1. Betti R., Bombonato C., Cerri A., Moneghini L., Menni S. Unusual sites for poromas are not very unusual: A survey of 101 cases. Clin. Exp. Dermatol. 2014;39:119–122. doi: 10.1111/ced.12185. - DOI - PubMed
    1. Chen C.-C., Chang Y.-T., Liu H.-N. Clinical and histological characteristics of poroid neoplasms: A study of 25 cases in Taiwan. Int. J. Dermatol. 2006;45:722–727. doi: 10.1111/j.1365-4632.2006.02741.x. - DOI - PubMed

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