Restricted expression of measles virus proteins in brains from cases of subacute sclerosing panencephalitis - PubMed (original) (raw)
Restricted expression of measles virus proteins in brains from cases of subacute sclerosing panencephalitis
U G Liebert et al. J Gen Virol. 1986 Nov.
Abstract
The presence of five structural proteins of measles virus in brain material obtained at autopsy from four patients with subacute sclerosing panencephalitis (SSPE) was examined by immunofluorescence employing monoclonal antibodies. In addition, the humoral immune response against measles virus antigens in serum and cerebrospinal fluid was analysed by immunoprecipitation in combination with gel electrophoresis, revealing a reduced response mainly to the matrix (M) protein. In none of the brain material were all five structural proteins simultaneously detected. Nucleocapsid protein and phosphoprotein were found in every diseased brain area, whereas haemagglutinin (H) protein was detected in two, fusion (F) protein in three and M protein only in one SSPE case. In two cases, variations in the occurrence of H and F proteins could be observed between regions displaying different degrees of neuropathological changes. No correlation was observed between the humoral immune response and the immunohistological findings. These data support the hypothesis of a restricted synthesis of measles virus proteins, in particular the envelope and M proteins, in SSPE.
Similar articles
- Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis.
Hall WW, Lamb RA, Choppin PW. Hall WW, et al. Proc Natl Acad Sci U S A. 1979 Apr;76(4):2047-51. doi: 10.1073/pnas.76.4.2047. Proc Natl Acad Sci U S A. 1979. PMID: 287042 Free PMC article. - Antibody response to structural proteins of measles virus in patients with natural measles and subacute sclerosing panencephalitis.
Sato TA, Hayami M, Yamanouchi K. Sato TA, et al. Jpn J Med Sci Biol. 1981 Dec;34(6):365-73. doi: 10.7883/yoken1952.34.365. Jpn J Med Sci Biol. 1981. PMID: 7334708 - [Subacute sclerosing panencephalitis].
Andzhaparidze OG, Bogomolova NN. Andzhaparidze OG, et al. Vopr Virusol. 1983 Nov-Dec;28(6):644-7. Vopr Virusol. 1983. PMID: 6367219 Review. Russian. No abstract available. - Molecular events in measles virus infection of the central nervous system.
Swoveland PT. Swoveland PT. Int Rev Exp Pathol. 1991;32:255-75. doi: 10.1016/b978-0-12-364932-4.50011-3. Int Rev Exp Pathol. 1991. PMID: 1864706 Review. No abstract available.
Cited by
- Brain tropism acquisition: The spatial dynamics and evolution of a measles virus collective infectious unit that drove lethal subacute sclerosing panencephalitis.
Yousaf I, Hannon WW, Donohue RC, Pfaller CK, Yadav K, Dikdan RJ, Tyagi S, Schroeder DC, Shieh WJ, Rota PA, Feder AF, Cattaneo R. Yousaf I, et al. PLoS Pathog. 2023 Dec 21;19(12):e1011817. doi: 10.1371/journal.ppat.1011817. eCollection 2023 Dec. PLoS Pathog. 2023. PMID: 38127684 Free PMC article. - Epitranscriptomic marks: Emerging modulators of RNA virus gene expression.
Netzband R, Pager CT. Netzband R, et al. Wiley Interdiscip Rev RNA. 2020 May;11(3):e1576. doi: 10.1002/wrna.1576. Epub 2019 Nov 6. Wiley Interdiscip Rev RNA. 2020. PMID: 31694072 Free PMC article. Review. - Measles Encephalitis: Towards New Therapeutics.
Ferren M, Horvat B, Mathieu C. Ferren M, et al. Viruses. 2019 Nov 2;11(11):1017. doi: 10.3390/v11111017. Viruses. 2019. PMID: 31684034 Free PMC article. Review. - Cryopreservation of Canine Primary Dorsal Root Ganglion Neurons and Its Impact upon Susceptibility to Paramyxovirus Infection.
Schwarz S, Spitzbarth I, Baumgärtner W, Lehmbecker A. Schwarz S, et al. Int J Mol Sci. 2019 Feb 28;20(5):1058. doi: 10.3390/ijms20051058. Int J Mol Sci. 2019. PMID: 30823498 Free PMC article. - Keeping it in check: chronic viral infection and antiviral immunity in the brain.
Miller KD, Schnell MJ, Rall GF. Miller KD, et al. Nat Rev Neurosci. 2016 Dec;17(12):766-776. doi: 10.1038/nrn.2016.140. Epub 2016 Nov 4. Nat Rev Neurosci. 2016. PMID: 27811921 Free PMC article. Review.