Innovation in insecticide discovery: Approaches to the discovery of new classes of insecticides - PubMed (original) (raw)

Review

. 2022 Aug;78(8):3226-3247.

doi: 10.1002/ps.6942. Epub 2022 May 22.

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• PMID: 35452182
• DOI: 10.1002/ps.6942

Review

Innovation in insecticide discovery: Approaches to the discovery of new classes of insecticides

Thomas C Sparks et al. Pest Manag Sci. 2022 Aug.

Abstract

The continuing demand for agrochemical insecticides that can meet increasing grower, environmental, consumer and regulatory requirements creates the need for the development of new solutions for managing crop pest insects. The development of resistance to the currently available insecticidal products adds another critical driver for new insecticidal active ingredients (AIs). One avenue to meeting these challenges is the creation of new classes of insecticidal molecules to act as starting points and prototypes stimulating further spectrum, efficacy and environmental impact refinements. A new class of insecticides is foreshadowed by the first molecule exemplifying that class (first-in-class, FIC) and offers one measure of innovation within the agrochemical industry. Most insecticides owe their discovery to competitor-inspired (i.e. competitor patents/products) or next-generation (follow-on to a company's pre-existing product) strategies. In contrast, FIC insecticides primarily emerge from a bioactive hypothesis approach, with the largest segment resulting from the exploration of new areas of chemistry/heterocycles and underexploited motifs. Natural products also play an important role in the discovery of FIC insecticides. Understanding the origins of these FIC compounds and the approaches used in their discovery can provide insights into successful strategies for future FIC insecticides. This review analyses information on historic and recently introduced FIC insecticides. Its main objective has been to identify the most successful discovery strategies for identifying new agrochemical solutions to meet the challenge of minimizing crop losses resulting from insects. © 2022 Society of Chemical Industry.

Keywords: agrochemical industry; competitor-inspired; crop protection compounds; first-in-class; insecticide discovery; natural products.

© 2022 Society of Chemical Industry.

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