The deafferented reticular thalamic nucleus generates spindle rhythmicity - PubMed (original) (raw)
The deafferented reticular thalamic nucleus generates spindle rhythmicity
M Steriade et al. J Neurophysiol. 1987 Jan.
Abstract
The hypothesis that nucleus reticularis thalami (RE) is the generator of spindle rhythmicity during electroencephalogram (EEG) synchronization was tested in acutely prepared cats. Unit discharges and focal waves were extracellularly recorded in the rostral pole of RE nucleus, which was completely disconnected by transections from all other thalamic nuclei. In some experiments, additional transections through corona radiata created a triangular island in which the rostral RE pole survived with the caudate nucleus, putamen, basal forebrain nuclei, prepyriform area, and the adjacent cortex. Similar results were obtained in two types of experiments: brain stem-transected preparations that exhibited spontaneous spindle sequences, and animals under ketamine anesthesia in which transient spindling was repeatedly precipitated during recording by very low doses of a short-acting barbiturate. Both spindle-related rhythms (7- to 16-Hz waves grouped in sequences that recur with a rhythm of 0.1-0.3 Hz) are seen in focal recordings of the deafferented RE nucleus. The presence of spindling rhythmicity in the disconnected RE nucleus contrasts with total absence of spindles in cortical EEG leads and in thalamic recordings behind the transection. Oscillations within the same frequency range as that of spontaneous spindles can be evoked in the deafferented RE nucleus by subcortical white matter stimulation. In deafferented RE cells, the burst structure consists of an initially biphasic acceleration-deceleration pattern, eventually leading to a long-lasting tonic tail. Quantitative group data show that the burst parameters of disconnected RE cells are very similar to those of RE neurons with intact connections. In the deafferented RE nucleus, spike bursts of RE neurons recur periodically (0.1-0.3 Hz) in close time-relation with simultaneously recorded focal spindle sequences. The burst occurrence of deafferented RE cells is greatly reduced after systemic administration of bicuculline. The preservation of both spindle-related rhythms in the disconnected RE nucleus, together with our recent experiments showing abolition of spindle oscillations in thalamic nuclei after lesions of RE nucleus (24), demonstrate that RE nucleus is the generator of spindle rhythms.
Similar articles
- Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami.
Steriade M, Deschênes M, Domich L, Mulle C. Steriade M, et al. J Neurophysiol. 1985 Dec;54(6):1473-97. doi: 10.1152/jn.1985.54.6.1473. J Neurophysiol. 1985. PMID: 4087044 - Physiological characteristics of anterior thalamic nuclei, a group devoid of inputs from reticular thalamic nucleus.
Paré D, Steriade M, Deschênes M, Oakson G. Paré D, et al. J Neurophysiol. 1987 Jun;57(6):1669-85. doi: 10.1152/jn.1987.57.6.1669. J Neurophysiol. 1987. PMID: 3037038 - Low-frequency rhythms in the thalamus of intact-cortex and decorticated cats.
Timofeev I, Steriade M. Timofeev I, et al. J Neurophysiol. 1996 Dec;76(6):4152-68. doi: 10.1152/jn.1996.76.6.4152. J Neurophysiol. 1996. PMID: 8985908 - The reticular nucleus revisited: intrinsic and network properties of a thalamic pacemaker.
Fuentealba P, Steriade M. Fuentealba P, et al. Prog Neurobiol. 2005 Feb;75(2):125-41. doi: 10.1016/j.pneurobio.2005.01.002. Prog Neurobiol. 2005. PMID: 15784303 Review. - The thalamic reticular nucleus: A common nucleus of neuropsychiatric diseases and deep brain stimulation.
Gerardo CM, Manuel MV. Gerardo CM, et al. J Clin Neurosci. 2020 Mar;73:1-7. doi: 10.1016/j.jocn.2020.01.061. Epub 2020 Jan 27. J Clin Neurosci. 2020. PMID: 32001110 Review.
Cited by
- Early Disruption of Cortical Sleep-Related Oscillations in a Mouse Model of Dementia With Lewy Bodies (DLB) Expressing Human Mutant (A30P) Alpha-Synuclein.
Stylianou M, Zaaimi B, Thomas A, Taylor JP, LeBeau FEN. Stylianou M, et al. Front Neurosci. 2020 Sep 17;14:579867. doi: 10.3389/fnins.2020.579867. eCollection 2020. Front Neurosci. 2020. PMID: 33041770 Free PMC article. - Density and frequency caudo-rostral gradients of sleep spindles recorded in the human cortex.
Peter-Derex L, Comte JC, Mauguière F, Salin PA. Peter-Derex L, et al. Sleep. 2012 Jan 1;35(1):69-79. doi: 10.5665/sleep.1588. Sleep. 2012. PMID: 22215920 Free PMC article. - Large-scale structure and individual fingerprints of locally coupled sleep oscillations.
Cox R, Mylonas DS, Manoach DS, Stickgold R. Cox R, et al. Sleep. 2018 Dec 1;41(12):zsy175. doi: 10.1093/sleep/zsy175. Sleep. 2018. PMID: 30184179 Free PMC article. - Electrical synapses in the thalamic reticular nucleus.
Landisman CE, Long MA, Beierlein M, Deans MR, Paul DL, Connors BW. Landisman CE, et al. J Neurosci. 2002 Feb 1;22(3):1002-9. doi: 10.1523/JNEUROSCI.22-03-01002.2002. J Neurosci. 2002. PMID: 11826128 Free PMC article. - Prolonged hyperpolarizing potentials precede spindle oscillations in the thalamic reticular nucleus.
Fuentealba P, Timofeev I, Steriade M. Fuentealba P, et al. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9816-21. doi: 10.1073/pnas.0402761101. Epub 2004 Jun 21. Proc Natl Acad Sci U S A. 2004. PMID: 15210981 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous