Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain - PubMed (original) (raw)

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Treatment of relapsing Clostridium difficile diarrhoea by administration of a non-toxigenic strain

D Seal et al. Eur J Clin Microbiol. 1987 Feb.

Abstract

Two patients with relapsing Clostridium difficile diarrhoea following metronidazole and vancomycin therapy were colonised with a non-toxigenic avirulent Clostridium difficile strain given orally in three doses. Both patients appeared to respond without side-effects. Oral bacteriotherapy with a defined nontoxigenic strain of Clostridium difficile would appear to represent an acceptable, alternative and novel way to treat hospitalised patients who relapse with Clostridium difficile diarrhoea after specific antibiotic therapy.

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