Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen - PubMed (original) (raw)
- PMID: 3574604
- DOI: 10.1159/000124737
Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen
T R Akesson et al. Neuroendocrinology. 1987 Apr.
Abstract
Although there is a good correlation between the levels of gonadal steroids and sex differences in reproductive behavior and food intake, the neurochemical mechanisms by which a gonadal steroid may regulate these behaviors remain unknown. An important central nervous site for steroid modulation of food intake and reproduction is the ventromedial nucleus of the hypothalamus (VMH). Recently it has been suggested that some of the activities of the VMH are dependent on the neuroactive peptide cholecystokinin octapeptide (CCK). High levels of CCK in the VMH have been measured by radioimmunoassay, and immunohistochemical analysis has revealed a dense plexus of CCK fibers and terminals which appose and make synaptic contact with VMH neurons. There is, however, a paucity of information concerning the presence of CCK-binding sites in the VMH. This study demonstrates high levels of 125I-CCK8 binding in the VMH of male and female rats. Tissue sampled on the morning of estrus revealed depressed levels of CCK binding, and, while ovariectomy itself did not affect binding, ovariectomy followed by estrogen replacement depressed CCK binding. These results provide evidence for an estrogenic effect on CCK-binding sites that may help elucidate a role of CCK in the VMH.
Similar articles
- Regulation of cholecystokinin receptors in the ventromedial nucleus of the hypothalamus: sex steroid hormone effects.
Popper P, Priest CA, Micevych PE. Popper P, et al. Brain Res. 1996 Mar 18;712(2):335-9. doi: 10.1016/0006-8993(95)01561-2. Brain Res. 1996. PMID: 8814910 - Injections of cholecystokinin into the ventromedial hypothalamic nucleus inhibit lordosis behavior in the rat.
Babcock AM, Block GJ, Micevych PE. Babcock AM, et al. Physiol Behav. 1988;43(2):195-9. doi: 10.1016/0031-9384(88)90237-5. Physiol Behav. 1988. PMID: 3212055 - Binding of [3H]cholecystokinin in the ventromedial hypothalamus is modulated by an afferent brainstem projection but not by ovarian steroids.
Schumacher M, Coirini H, McEwen BS, Záborszky L. Schumacher M, et al. Brain Res. 1991 Nov 8;564(1):102-8. doi: 10.1016/0006-8993(91)91358-8. Brain Res. 1991. PMID: 1777814 - The regulation of oxytocin receptor binding in the ventromedial hypothalamic nucleus by gonadal steroids.
Johnson AE. Johnson AE. Ann N Y Acad Sci. 1992 Jun 12;652:357-73. doi: 10.1111/j.1749-6632.1992.tb34367.x. Ann N Y Acad Sci. 1992. PMID: 1320831 Review. - Ovarian hormone action in the hypothalamic ventromedial nucleus: remodelling to regulate reproduction.
Griffin GD, Flanagan-Cato LM. Griffin GD, et al. J Neuroendocrinol. 2011 Jun;23(6):465-71. doi: 10.1111/j.1365-2826.2011.02143.x. J Neuroendocrinol. 2011. PMID: 21518031 Free PMC article. Review.
Cited by
- Sex differences in the neural circuit that mediates female sexual receptivity.
Flanagan-Cato LM. Flanagan-Cato LM. Front Neuroendocrinol. 2011 Apr;32(2):124-36. doi: 10.1016/j.yfrne.2011.02.008. Epub 2011 Feb 19. Front Neuroendocrinol. 2011. PMID: 21338620 Free PMC article. Review. - Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway.
Simerly RB, Young BJ, Capozza MA, Swanson LW. Simerly RB, et al. Proc Natl Acad Sci U S A. 1989 Jun;86(12):4766-70. doi: 10.1073/pnas.86.12.4766. Proc Natl Acad Sci U S A. 1989. PMID: 2471980 Free PMC article. - Modular genetic control of sexually dimorphic behaviors.
Xu X, Coats JK, Yang CF, Wang A, Ahmed OM, Alvarado M, Izumi T, Shah NM. Xu X, et al. Cell. 2012 Feb 3;148(3):596-607. doi: 10.1016/j.cell.2011.12.018. Cell. 2012. PMID: 22304924 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources