A simple model of the build-up of resistance to mixtures of anti-malarial drugs - PubMed (original) (raw)

Comparative Study

A simple model of the build-up of resistance to mixtures of anti-malarial drugs

C F Curtis et al. Trans R Soc Trop Med Hyg. 1986.

Abstract

In an organism with a life-cycle modelled on that of Plasmodium two separate resistance genes are assumed, each protecting against one of two unrelated drugs. The model was used to compare the rates of build-up of resistance in a population where the two drugs are used either as a mixture or in sequence. The model suggests that the use of a mixture would be advantageous if: both resistances are initially rare; there is recombination between the genes; a large proportion of the parasite population is unexposed to the drugs.

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