The glucose-regulated protein grp94 is related to heat shock protein hsp90 - PubMed (original) (raw)
Comparative Study
The glucose-regulated protein grp94 is related to heat shock protein hsp90
P K Sorger et al. J Mol Biol. 1987.
Abstract
We report the sequence of a cDNA clone that encodes the C-terminal half of the hamster 94 X 10(3) Mr glucose-regulated protein, grp94. The amino acid sequence of this protein is about 50% homologous to Drosophila hsp83 and yeast hsp90, suggesting that grp94 and hsp90 have similar functional properties. Unlike hsp90, grp94 is associated with the endoplasmic reticulum. It has the same C-terminal tetrapeptide as two other luminal endoplasmic reticulum proteins, grp78 and protein disulphide isomerase. We suggest that this sequence forms part of a signal for retention of proteins in the lumen of the endoplasmic reticulum.
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