Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development - PubMed (original) (raw)
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
M Monk et al. Development. 1987 Mar.
Abstract
This paper shows stage- and tissue-specific global demethylation and remethylation occurring during embryonic development. The egg genome is strikingly undermethylated and the sperm genome relatively methylated. Following a loss of genomic methylation during preimplantation development, embryonic and extraembryonic lineages are progressively and independently methylated to different final extents. Methylation continues postgastrulation and hence could be a mechanism initiating, or confirming, differential programming in the definitive germ layers. It is proposed that much of the methylation observed in somatic tissues acts to stabilize and reinforce prior events that regulate the activity of specific genes, chromosome domains or the X chromosome (in females). Fetal germ cell DNA is markedly undermethylated and we favour the idea that the germ lineage is set aside before the occurrence of extensive methylation of DNA in fetal precursor cells.
Similar articles
- Developmental pattern of gene-specific DNA methylation in the mouse embryo and germ line.
Kafri T, Ariel M, Brandeis M, Shemer R, Urven L, McCarrey J, Cedar H, Razin A. Kafri T, et al. Genes Dev. 1992 May;6(5):705-14. doi: 10.1101/gad.6.5.705. Genes Dev. 1992. PMID: 1577268 - Changes in DNA methylation during mouse embryonic development in relation to X-chromosome activity and imprinting.
Monk M. Monk M. Philos Trans R Soc Lond B Biol Sci. 1990 Jan 30;326(1235):299-312. doi: 10.1098/rstb.1990.0013. Philos Trans R Soc Lond B Biol Sci. 1990. PMID: 1968666 - Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes.
Tomizawa S, Kobayashi H, Watanabe T, Andrews S, Hata K, Kelsey G, Sasaki H. Tomizawa S, et al. Development. 2011 Mar;138(5):811-20. doi: 10.1242/dev.061416. Epub 2011 Jan 19. Development. 2011. PMID: 21247965 Free PMC article. - Germline-derived DNA methylation and early embryo epigenetic reprogramming: The selected survival of imprints.
Monk D. Monk D. Int J Biochem Cell Biol. 2015 Oct;67:128-38. doi: 10.1016/j.biocel.2015.04.014. Epub 2015 May 9. Int J Biochem Cell Biol. 2015. PMID: 25966912 Review. - Epigenetic reprogramming in mammalian development.
Reik W, Dean W, Walter J. Reik W, et al. Science. 2001 Aug 10;293(5532):1089-93. doi: 10.1126/science.1063443. Science. 2001. PMID: 11498579 Review.
Cited by
- Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells.
Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT. Vincent JJ, et al. Cell Stem Cell. 2013 Apr 4;12(4):470-8. doi: 10.1016/j.stem.2013.01.016. Epub 2013 Feb 14. Cell Stem Cell. 2013. PMID: 23415914 Free PMC article. - Maintenance of Epigenetic Information.
Almouzni G, Cedar H. Almouzni G, et al. Cold Spring Harb Perspect Biol. 2016 May 2;8(5):a019372. doi: 10.1101/cshperspect.a019372. Cold Spring Harb Perspect Biol. 2016. PMID: 27141050 Free PMC article. Review. - DNA methylation: a timeline of methods and applications.
Harrison A, Parle-McDermott A. Harrison A, et al. Front Genet. 2011 Oct 25;2:74. doi: 10.3389/fgene.2011.00074. eCollection 2011. Front Genet. 2011. PMID: 22303369 Free PMC article. - A single day of 5-azacytidine exposure during development induces neurodegeneration in neonatal mice and neurobehavioral deficits in adult mice.
Subbanna S, Nagre NN, Shivakumar M, Basavarajappa BS. Subbanna S, et al. Physiol Behav. 2016 Dec 1;167:16-27. doi: 10.1016/j.physbeh.2016.08.036. Epub 2016 Sep 1. Physiol Behav. 2016. PMID: 27594097 Free PMC article. - The epigenetics of maternal cigarette smoking during pregnancy and effects on child development.
Knopik VS, Maccani MA, Francazio S, McGeary JE. Knopik VS, et al. Dev Psychopathol. 2012 Nov;24(4):1377-90. doi: 10.1017/S0954579412000776. Dev Psychopathol. 2012. PMID: 23062304 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources