Antibiotic cost savings from formulary restrictions and physician monitoring in a medical-school-affiliated hospital - PubMed (original) (raw)
Comparative Study
Antibiotic cost savings from formulary restrictions and physician monitoring in a medical-school-affiliated hospital
R S Woodward et al. Am J Med. 1987 Nov.
Abstract
Strictly enforced formulary restrictions for aminoglycosides, cephalosporins, and a vancomycin group generated combined savings of 2.61(plessthan0.0046)perantibioticdayand2.61 (p less than 0.0046) per antibiotic day and 2.61(plessthan0.0046)perantibioticdayand34,597 (p less than 0.0003) per month. Even after some cost increases (not significant) in new and other antibiotics, the program saved 1.33(plessthan0.0175)perantibioticdayand1.33 (p less than 0.0175) per antibiotic day and 1.33(plessthan0.0175)perantibioticdayand24,620 (p less than 0.0311) per month for all antibiotics. The pharmacy's 1985 average cost per antibiotic day and its monthly expenditures were 18.45and18.45 and 18.45and199,003, respectively. In the months following the formulary restrictions, no significant detrimental changes occurred in hospital length of stay or mortality. A retrospective analysis of 322 patients with bacteremia treated before and after the onset of the controls revealed that antibiotics were more appropriately used afterwards.
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