Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation - PubMed (original) (raw)
Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation
H Rohrer et al. J Neurosci. 1987 Nov.
Abstract
A population of undifferentiated cells has been characterized during the early development of nodose and ciliary ganglia. This population is defined by the absence of surface markers specific for neurons (tetanus toxin receptor, Q211 antigen) and for glial cells (O4 antigen). These undifferentiated cell populations were isolated from the ganglia and were shown to contain neuronal precursor cells that were able to differentiate in vitro into neurons, as characterized by morphology and surface antigens. Undifferentiated cells were detected during the period of neuronal birth, indicating that dividing neuronal precursor cells do not express neuron-specific surface markers. This was directly shown by 3H-thymidine-labeling studies using nodose ganglia, ciliary ganglia, and dorsal root ganglia. In sympathetic ganglia, however, no undifferentiated neuronal precursor cells were detectable at developmental stages when sympathetic neurons are born. 3H-Thymidine injected during that stage at E7 was incorporated into cells expressing the neuronal markers tetanus toxin receptor and Q211 antigen. Quantitative fluorimetric determination of the DNA content of dissociated sympathetic ganglion cells demonstrated the presence of a population of Q211-positive sympathetic ganglion cells in the G2 phase of the cell cycle. E7 sympathetic ganglion cells expressing neuronal surface markers were also shown to be able to divide in vitro. We have concluded that the relationship between terminal mitosis and the onset of differentiation differs between ganglia of the chick peripheral nervous system: Sympathetic ganglion cells continue to divide after the acquisition of neuronal properties, whereas neuronal precursor cells from other autonomic and sensory ganglia start to differentiate after a terminal mitosis.
Similar articles
- Onset of CNTFRalpha expression and signal transduction during neurogenesis in chick sensory dorsal root ganglia.
Holst A, Heller S, Junghans D, Geissen M, Ernsberger U, Rohrer H. Holst A, et al. Dev Biol. 1997 Nov 1;191(1):1-13. doi: 10.1006/dbio.1997.8714. Dev Biol. 1997. PMID: 9356167 - In vitro identification of dividing neuronal precursors from chick embryonic ciliary ganglion.
Gilardino A, Perroteau I, Lovisolo D, Distasi C. Gilardino A, et al. Neuroreport. 2000 Apr 27;11(6):1209-12. doi: 10.1097/00001756-200004270-00013. Neuroreport. 2000. PMID: 10817593 - Satellite glial cells in sympathetic and parasympathetic ganglia: in search of function.
Hanani M. Hanani M. Brain Res Rev. 2010 Sep 24;64(2):304-27. doi: 10.1016/j.brainresrev.2010.04.009. Epub 2010 May 2. Brain Res Rev. 2010. PMID: 20441777 Review. - Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia.
Ernsberger U. Ernsberger U. Cell Tissue Res. 2009 Jun;336(3):349-84. doi: 10.1007/s00441-009-0784-z. Epub 2009 Apr 23. Cell Tissue Res. 2009. PMID: 19387688 Review.
Cited by
- The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system.
Ernsberger U, Deller T, Rohrer H. Ernsberger U, et al. Cell Tissue Res. 2021 Dec;386(3):455-475. doi: 10.1007/s00441-021-03548-y. Epub 2021 Nov 10. Cell Tissue Res. 2021. PMID: 34757495 Free PMC article. Review. - Development of the Autonomic Nervous System: Clinical Implications.
Lefcort F. Lefcort F. Semin Neurol. 2020 Oct;40(5):473-484. doi: 10.1055/s-0040-1713926. Epub 2020 Sep 14. Semin Neurol. 2020. PMID: 32927484 Free PMC article. Review. - Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development.
Joseph C, Mangani AS, Gupta V, Chitranshi N, Shen T, Dheer Y, Kb D, Mirzaei M, You Y, Graham SL, Gupta V. Joseph C, et al. Aging Dis. 2020 Jul 23;11(4):946-966. doi: 10.14336/AD.2019.0923. eCollection 2020 Jul. Aging Dis. 2020. PMID: 32765956 Free PMC article. Review. - Neural crest development: insights from the zebrafish.
Rocha M, Singh N, Ahsan K, Beiriger A, Prince VE. Rocha M, et al. Dev Dyn. 2020 Jan;249(1):88-111. doi: 10.1002/dvdy.122. Epub 2019 Oct 22. Dev Dyn. 2020. PMID: 31591788 Free PMC article. Review. - Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia.
Vivancos Stalin L, Gualandi M, Schulte JH, Renella R, Shakhova O, Mühlethaler-Mottet A. Vivancos Stalin L, et al. Front Oncol. 2019 Apr 16;9:275. doi: 10.3389/fonc.2019.00275. eCollection 2019. Front Oncol. 2019. PMID: 31058082 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources