Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours - PubMed (original) (raw)
Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours
J A Raleigh et al. Br J Cancer. 1987 Oct.
Free PMC article
Abstract
Polyclonal antibodies have been raised in rabbits to a haemocyanin adduct of a reductively-activated, fluorinated analogue of misonidazole. Fluorescence immunohistochemical studies show that the polyclonal antibodies bind to spheroid sections and tumour sections in patterns similar to those revealed by autoradiographic studies with a tritium-labelled derivative of the fluorinated misonidazole analogue.
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