Independent and Synergistic Associations of Aerobic Physical Activity and Resistance Exercise with Nonalcoholic Fatty Liver Disease - PubMed (original) (raw)

. 2023 Jul 15;17(4):600-609.

doi: 10.5009/gnl220345. Epub 2023 Mar 17.

Affiliations

Independent and Synergistic Associations of Aerobic Physical Activity and Resistance Exercise with Nonalcoholic Fatty Liver Disease

Hong Jun Yang et al. Gut Liver. 2023.

Abstract

Background/aims: This study aimed to examine the independent and synergistic association of aerobic physical activity and resistance exercise with nonalcoholic fatty liver disease (NAFLD) using a nationwide representative database.

Methods: This was a cross-sectional study using data from the Korea National Health and Nutritional Examination Survey between 2007 and 2010. Multiple logistic regression models were used to examine the independent and synergistic (additive interaction) associations of aerobic physical activity and resistance exercise with NAFLD after adjusting for multiple covariates.

Results: The prevalence of NAFLD was 26.2% for men and 17.6% for women. In the fully adjusted multiple logistic regression model to examine the independent association of aerobic physical activity or resistance exercise with NAFLD, the odds ratios for NAFLD were significantly decreased in both men (p=0.03) and women (p<0.01) who had highly active aerobic physical activity. Regarding the frequency of resistance exercise, the odds ratio for NAFLD was decreased in men who did resistance exercise ≥5 days per week (p=0.04), but not in women (p=0.19). However, when investigating the synergistic associations of aerobic physical activity and resistance exercise, the odds ratios for NAFLD significantly decreased when the frequency of both exercises increased together in both men (p for interaction <0.01) and women (p for interaction<0.01).

Conclusions: Combining aerobic physical activity and resistance exercise had a synergistic preventive association for NAFLD in Korean men and women.

Keywords: Non-alcoholic fatty liver disease; Physical activity; Resistance training.

PubMed Disclaimer

Conflict of interest statement

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1

Fig. 1

Adjusted odds ratio of aerobic physical activity for nonalcoholic fatty liver disease (NAFLD) among Korean men and women. Multiple logistic regression models for NAFLD were used after adjusting for age, resistance exercise, body mass index, waist circumference, smoking status, alcohol intake, diabetes mellitus, hypertension, total cholesterol, high-density lipoprotein cholesterol, income level and education level by sex. Physical activity level was divided into three categories based on metabolic equivalent minutes per week: inactive, minimally active, highly active group.

Fig. 2

Fig. 2

Adjusted odds ratio of resistance exercise for nonalcoholic fatty liver disease (NAFLD) among Korean men and women. Multiple logistic regression models for NAFLD were used after adjusting for age, aerobic physical activity exercise, body mass index, waist circumference, smoking status, alcohol intake, diabetes mellitus, hypertension, total cholesterol, high-density lipoprotein cholesterol, income level and education level by sex. Frequency of resistance exercise was divided into three categories: 0-1 day/wk, 2-4 day/wk, ≥5 day/wk.

Fig. 3

Fig. 3

(A) Prevalence of NAFLD was presented as bar graph according to the level of physical activity and the frequency of resistance exercise among Korean men. (B) Prevalence of NAFLD was presented as bar graph according to the level of physical activity and the frequency of resistance exercise among Korean women.

Comment in

References

    1. Murag S, Ahmed A, Kim D. Recent epidemiology of nonalcoholic fatty liver disease. Gut Liver. 2021;15:206–216. doi: 10.5009/gnl20127. - DOI - PMC - PubMed
    1. Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease: meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64:73–84. doi: 10.1002/hep.28431. - DOI - PubMed
    1. Li J, Zou B, Yeo YH, et al. Prevalence, incidence, and outcome of non-alcoholic fatty liver disease in Asia, 1999-2019: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2019;4:389–398. doi: 10.1016/S2468-1253(19)30039-1. - DOI - PubMed
    1. Kang SY, Kim YJ, Park HS. Trends in the prevalence of non-alcoholic fatty liver disease and its future predictions in Korean men, 1998-2035. J Clin Med. 2020;9:2626. doi: 10.3390/jcm9082626.a6fb02179f63465abac854381e50126d - DOI - PMC - PubMed
    1. Nseir W, Hellou E, Assy N. Role of diet and lifestyle changes in nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20:9338–9344. doi: 10.3748/wjg.v20.i28.9338. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources