Influence of inflammatory bowel disease on intestinal microflora - PubMed (original) (raw)

Comparative Study

Influence of inflammatory bowel disease on intestinal microflora

M R Keighley et al. Gut. 1978 Dec.

Abstract

The microflora of the jejunum, ileum, and colon has been studied from operative samples in Crohn's disease (n = 30), ulcerative colitis (n = 15), and controls (n = 40). There was no significant difference in the flora of patients with ulcerative colitis compared with controls. In Crohn's disease there was a significant increase in E. coli (P less than 0.001) and B. fragilis (P less than 0.001) in the ileum and of E. coli (P less than 0.001) and lactobacilli (P less than 0.01) in the colon. The abnormal ileal flora in Crohn's disease was unrelated to serological evidence of disease activity (indices: ESR, serum albumin, serum seromucoids), diameter of the ileum, or excision of the ileocaecal valve. The abnormal colonic flora in Crohn's disease was not related to presence of macroscopic colitis.

PubMed Disclaimer

Similar articles

• Molecular characterization of rectal mucosa-associated bacterial flora in inflammatory bowel disease.
  Mylonaki M, Rayment NB, Rampton DS, Hudspith BN, Brostoff J. Mylonaki M, et al. Inflamm Bowel Dis. 2005 May;11(5):481-7. doi: 10.1097/01.mib.0000159663.62651.4f. Inflamm Bowel Dis. 2005. PMID: 15867588
• Differences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis.
  Gophna U, Sommerfeld K, Gophna S, Doolittle WF, Veldhuyzen van Zanten SJ. Gophna U, et al. J Clin Microbiol. 2006 Nov;44(11):4136-41. doi: 10.1128/JCM.01004-06. Epub 2006 Sep 20. J Clin Microbiol. 2006. PMID: 16988016 Free PMC article.
• The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique.
  Giaffer MH, Holdsworth CD, Duerden BI. Giaffer MH, et al. J Med Microbiol. 1991 Oct;35(4):238-43. doi: 10.1099/00222615-35-4-238. J Med Microbiol. 1991. PMID: 1941994 Clinical Trial.
• Role of antibiotics for treatment of inflammatory bowel disease.
  Nitzan O, Elias M, Peretz A, Saliba W. Nitzan O, et al. World J Gastroenterol. 2016 Jan 21;22(3):1078-87. doi: 10.3748/wjg.v22.i3.1078. World J Gastroenterol. 2016. PMID: 26811648 Free PMC article. Review.
• [Role of intestinal flora in inflammatory bowel disease and probiotics place in their management].
  Belkahla N, Maamouri N, Ouerghi H, Ben Ammar A. Belkahla N, et al. Tunis Med. 2005 Mar;83(3):132-6. Tunis Med. 2005. PMID: 15929439 Review. French.

Cited by

• Inflammatory bowel disease biomarkers revealed by the human gut microbiome network.
  Hu M, Caldarelli G, Gili T. Hu M, et al. Sci Rep. 2023 Nov 8;13(1):19428. doi: 10.1038/s41598-023-46184-y. Sci Rep. 2023. PMID: 37940667 Free PMC article.
• Gastrointestinal dysbiosis and Escherichia coli pathobionts in inflammatory bowel diseases.
  Petersen AM. Petersen AM. APMIS. 2022 Aug;130 Suppl 144(Suppl 144):1-38. doi: 10.1111/apm.13256. APMIS. 2022. PMID: 35899316 Free PMC article. No abstract available.
• Dextran Sulphate Sodium Acute Colitis Rat Model: A Suitable Tool for Advancing Our Understanding of Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease.
  Adamkova P, Hradicka P, Kupcova Skalnikova H, Cizkova V, Vodicka P, Farkasova Iannaccone S, Kassayova M, Gancarcikova S, Demeckova V. Adamkova P, et al. Vet Sci. 2022 May 16;9(5):238. doi: 10.3390/vetsci9050238. Vet Sci. 2022. PMID: 35622766 Free PMC article.
• Effect of α-Hemolysin Producing E. coli in Two Different Mouse Strains in a DSS Model of Inflammatory Bowel Disease.
  Mirsepasi-Lauridsen HC, Struve C, Petersen AM, Krogfelt KA. Mirsepasi-Lauridsen HC, et al. Microorganisms. 2020 Dec 11;8(12):1971. doi: 10.3390/microorganisms8121971. Microorganisms. 2020. PMID: 33322398 Free PMC article.
• Ulcerative Colitis-associated E. coli pathobionts potentiate colitis in susceptible hosts.
  Yang H, Mirsepasi-Lauridsen HC, Struve C, Allaire JM, Sivignon A, Vogl W, Bosman ES, Ma C, Fotovati A, Reid GS, Li X, Petersen AM, Gouin SG, Barnich N, Jacobson K, Yu HB, Krogfelt KA, Vallance BA. Yang H, et al. Gut Microbes. 2020 Nov 9;12(1):1847976. doi: 10.1080/19490976.2020.1847976. Epub 2020 Dec 1. Gut Microbes. 2020. PMID: 33258388 Free PMC article.

References

1. 1. N Engl J Med. 1964 May 14;270:1050-6 CONCL - PubMed
2. 1. Lancet. 1963 Mar 9;1(7280):532-3 - PubMed
3. 1. Gastroenterology. 1958 May;34(5):910-9 - PubMed
4. 1. Ann R Coll Surg Engl. 1977 Jul;59(4):328-34 - PubMed
5. 1. Br J Surg. 1977 May;64(5):315-21 - PubMed

Publication types

MeSH terms

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • HighWire
  • PubMed Central

• Miscellaneous

  • NCI CPTAC Assay Portal