Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains - PubMed (original) (raw)
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains
D Young et al. Cell. 1986.
Abstract
We have cloned and sequenced a new human oncogene and have named it mas. This oncogene was detected by its tumorigenicity in nude mice using the cotransfection and tumorigenicity assay previously described. The mas oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. A DNA rearrangement in the 5' noncoding sequence, which occurred during transfection, is probably responsible for activation of the mas gene. The cDNA sequence of the mas oncogene reveals a long open reading frame that codes for a 325 amino acid protein. This protein is very hydrophobic and has seven potential transmembrane domains. In this respect, the structure of the mas protein is novel among cellular oncogene products and may reflect a new functional class of oncogenes.
Similar articles
- High frequency of mas oncogene activation detected in the NIH3T3 tumorigenicity assay.
van 't Veer LJ, van den Berg-Bakker LA, Hermens RP, Deprez RL, Schrier PI. van 't Veer LJ, et al. Oncogene Res. 1988;3(3):247-54. Oncogene Res. 1988. PMID: 3060802 - Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.
Young D, O'Neill K, Jessell T, Wigler M. Young D, et al. Proc Natl Acad Sci U S A. 1988 Jul;85(14):5339-42. doi: 10.1073/pnas.85.14.5339. Proc Natl Acad Sci U S A. 1988. PMID: 2455902 Free PMC article. - Activation of the mas oncogene involves coupling to human alphoid sequences.
van 't Veer LJ, van der Feltz MJ, van den Berg-Bakker CA, Cheng NC, Hermens RP, van Oorschot DA, Kievits T, Schrier PI. van 't Veer LJ, et al. Oncogene. 1993 Oct;8(10):2673-81. Oncogene. 1993. PMID: 8378079 - The role of non-ras transforming genes in chemical carcinogenesis.
Cooper CS. Cooper CS. Environ Health Perspect. 1991 Jun;93:33-40. doi: 10.1289/ehp.919333. Environ Health Perspect. 1991. PMID: 1685444 Free PMC article. Review. - Functional in vitro assays for the isolation of cell transformation effector and suppressor genes.
Zarbl H, Kho CJ, Boylan MO, Van Amsterdam J, Sullivan RC, Hoemann CD, Afshani VL. Zarbl H, et al. Environ Health Perspect. 1991 Jun;93:83-9. doi: 10.1289/ehp.919383. Environ Health Perspect. 1991. PMID: 1685446 Free PMC article. Review.
Cited by
- Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.
Gocayne J, Robinson DA, FitzGerald MG, Chung FZ, Kerlavage AR, Lentes KU, Lai J, Wang CD, Fraser CM, Venter JC. Gocayne J, et al. Proc Natl Acad Sci U S A. 1987 Dec;84(23):8296-300. doi: 10.1073/pnas.84.23.8296. Proc Natl Acad Sci U S A. 1987. PMID: 2825184 Free PMC article. - Targeting sphingosine-1-phosphate receptors in cancer.
Watters RJ, Wang HG, Sung SS, Loughran TP, Liu X. Watters RJ, et al. Anticancer Agents Med Chem. 2011 Nov;11(9):810-7. doi: 10.2174/187152011797655041. Anticancer Agents Med Chem. 2011. PMID: 21707490 Free PMC article. Review. - Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma.
Cesarman E, Nador RG, Bai F, Bohenzky RA, Russo JJ, Moore PS, Chang Y, Knowles DM. Cesarman E, et al. J Virol. 1996 Nov;70(11):8218-23. doi: 10.1128/JVI.70.11.8218-8223.1996. J Virol. 1996. PMID: 8892957 Free PMC article. - Many Faces of Renin-angiotensin System - Focus on Eye.
Holappa M, Vapaatalo H, Vaajanen A. Holappa M, et al. Open Ophthalmol J. 2017 Jun 19;11:122-142. doi: 10.2174/1874364101711010122. eCollection 2017. Open Ophthalmol J. 2017. PMID: 28761566 Free PMC article. Review. - GPCR-Gα13 Involvement in Mitochondrial Function, Oxidative Stress, and Prostate Cancer.
Wu D, Casey PJ. Wu D, et al. Int J Mol Sci. 2024 Jun 28;25(13):7162. doi: 10.3390/ijms25137162. Int J Mol Sci. 2024. PMID: 39000269 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases