Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota - PubMed (original) (raw)
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Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota
Yukun Liu et al. Biomed Pharmacother. 2023 Jul.
Free article
Abstract
Sepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regenerated or dysfunctional. The mechanism of sepsis-induced myopathy is currently unclear. It has been believed that this state is triggered by circulating pathogens and their related harmful factors, leading to impaired muscle metabolism. Sepsis and its resulting alterations in the intestinal microbiota are associated with sepsis-related organ dysfunction, including skeletal muscle wasting. There are also some studies on interventions targeting the flora, including fecal microbiota transplants, the addition of dietary fiber and probiotics in enteral feeding products, etc., aiming to improve sepsis-related myopathy. In this review, we critically assess the potential mechanisms and therapeutic prospects of intestinal flora in the development of septic myopathy.
Keywords: ICUAW; Infection; Microbiome; Muscle atrophy; Sepsis-induced myopathy.
Copyright © 2023. Published by Elsevier Masson SAS.
Conflict of interest statement
Declaration of Competing Interest The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.
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