Normal olfactory discrimination learning set and facilitation of reversal learning after medial-temporal damage in rats: implications for an account of preserved learning abilities in amnesia - PubMed (original) (raw)
Normal olfactory discrimination learning set and facilitation of reversal learning after medial-temporal damage in rats: implications for an account of preserved learning abilities in amnesia
H Eichenbaum et al. J Neurosci. 1986 Jul.
Abstract
Recent evidence of preserved skill learning in patients with "global" amnesia has led to the postulation of a qualitative distinction between functionally separate memory systems, one of which may remain preserved when the other is profoundly impaired. On one account, the separate memory systems support either the learning of declarative knowledge, i.e., facts and associations, or the learning of procedural knowledge, i.e., knowledge that permits the expression of skilled performance without reference to specific facts or associations. In an effort to develop a rodent model of amnesia that illustrates the same distinction between memory systems, rats were trained in a series of discrimination and reversal problems using olfaction, a sensory modality in which they rapidly learn new associations. Rats with bilateral fornix, amygdala, or combined fornix and amygdala damage learned successive two-odor discriminations as quickly as normal and sham-operated control subjects. Furthermore, all groups rapidly acquired the skills of discrimination as revealed in the development of a learning set. Subsequent presentation of a reversal of one discrimination elicited a marked dissociation among groups: Normal rats and rats with amygdala lesions required many more trials to acquire the reversal than to acquire a new discrimination problem, whereas rats with fornix lesions learned the reversal rather easily. A detailed analysis of response strategies suggested that normal rats and rats with amygdala lesions first extinguished the prior response tendencies and then abandoned the learning set skills and treated the reversal much as they did the initial discrimination problem.(ABSTRACT TRUNCATED AT 250 WORDS)
Similar articles
- Normal learning set and facilitation of reversal learning in rats with combined fornix-amygdala lesions: implications for preserved learning abilities in amnesia.
Fagan A, Eichenbaum H, Cohen N. Fagan A, et al. Ann N Y Acad Sci. 1985;444:510-2. doi: 10.1111/j.1749-6632.1985.tb37628.x. Ann N Y Acad Sci. 1985. PMID: 3860112 No abstract available. - Learning sets, discrimination reversal, and hippocampal function.
Fagan AM, Olton DS. Fagan AM, et al. Behav Brain Res. 1986 Jul;21(1):13-20. doi: 10.1016/0166-4328(86)90055-0. Behav Brain Res. 1986. PMID: 3741593 - Temporally graded retrograde amnesia following separate and combined lesions of the perirhinal cortex and fornix in the rat.
Wiig KA, Cooper LN, Bear MF. Wiig KA, et al. Learn Mem. 1996 Nov-Dec;3(4):313-25. doi: 10.1101/lm.3.4.313. Learn Mem. 1996. PMID: 10456101 - Preserved anterograde and retrograde memory of rapidly acquired olfactory discrminations after neurotoxic hippocampal lesions.
Jonasson Z, Ballantyne JK, Baxter MG. Jonasson Z, et al. Hippocampus. 2004;14(1):28-39. doi: 10.1002/hipo.10146. Hippocampus. 2004. PMID: 15058480 - In search of the neurobiological underpinnings of the differential outcomes effect.
Savage LM. Savage LM. Integr Physiol Behav Sci. 2001 Jul-Sep;36(3):182-95. doi: 10.1007/BF02734092. Integr Physiol Behav Sci. 2001. PMID: 11777014 Review.
Cited by
- Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors.
Shimshek DR, Bus T, Kim J, Mihaljevic A, Mack V, Seeburg PH, Sprengel R, Schaefer AT. Shimshek DR, et al. PLoS Biol. 2005 Nov;3(11):e354. doi: 10.1371/journal.pbio.0030354. Epub 2005 Oct 18. PLoS Biol. 2005. PMID: 16216087 Free PMC article. - Changes in functional connectivity in orbitofrontal cortex and basolateral amygdala during learning and reversal training.
Schoenbaum G, Chiba AA, Gallagher M. Schoenbaum G, et al. J Neurosci. 2000 Jul 1;20(13):5179-89. doi: 10.1523/JNEUROSCI.20-13-05179.2000. J Neurosci. 2000. PMID: 10864975 Free PMC article. - Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior.
Rudebeck PH, Izquierdo A. Rudebeck PH, et al. Neuropsychopharmacology. 2022 Jan;47(1):134-146. doi: 10.1038/s41386-021-01140-0. Epub 2021 Aug 18. Neuropsychopharmacology. 2022. PMID: 34408279 Free PMC article. Review. - Dynamic analysis of learning in behavioral experiments.
Smith AC, Frank LM, Wirth S, Yanike M, Hu D, Kubota Y, Graybiel AM, Suzuki WA, Brown EN. Smith AC, et al. J Neurosci. 2004 Jan 14;24(2):447-61. doi: 10.1523/JNEUROSCI.2908-03.2004. J Neurosci. 2004. PMID: 14724243 Free PMC article. - Hippocampal context processing is critical for interference free recall of odor memories in rats.
Butterly DA, Petroccione MA, Smith DM. Butterly DA, et al. Hippocampus. 2012 Apr;22(4):906-13. doi: 10.1002/hipo.20953. Epub 2011 May 3. Hippocampus. 2012. PMID: 21542056 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources