Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study - PubMed (original) (raw)
. 2023 Nov;55(11):1464-1471.
doi: 10.1016/j.dld.2023.07.014. Epub 2023 Aug 4.
Affiliations
- PMID: 37543433
- DOI: 10.1016/j.dld.2023.07.014
Association between the gut microbiota and nonalcoholic fatty liver disease: A two-sample Mendelian randomization study
Yu Li et al. Dig Liver Dis. 2023 Nov.
Abstract
Background: Increasing studies have shown that there is a significant association between gut microbiota and non-alcoholic fatty liver disease.
Aims: To show the potential association between gut microbiota and non-alcoholic fatty liver disease, we performed a two-sample Mendelian randomization analysis.
Methods: We analyzed summary statistics from genome-wide association studies of gut microbiota and non-alcoholic fatty liver disease and conducted Mendelian randomization studies to evaluate relationships between these factors.
Results: Of the 211 gut microbiota taxa examined, the inverse variance weighted method identified Lactobacillaceae (OR = 0.83, 95% CI = 0.72 - 0.95, P = 0.007), Christensenellaceae (OR = 0.74, 95% CI = 0.59 - 0.92, P = 0.007), and Intestinibacter (OR = 0.85, 95% CI = 0.73 - 0.99, P = 0.035) were negatively correlated with non-alcoholic fatty liver disease. And Coriobacteriia (OR = 1.22, 95% CI = 1.01 - 1.42, P = 0.038), Actinomycetales (OR = 1.25, 95% CI = 1.02 - 1.53, P = 0.031), Oxalobacteraceae (OR = 1.10, 95% CI = 1.01 - 1.21, P = 0.036), Ruminococcaceae_UCG005 (OR = 1.18, 95% CI = 1.01 - 1.38, P = 0.033) are positively associated with non-alcoholic fatty liver disease.
Conclusions: Our study found that the abundance of certain strains was associated with the progression of nonalcoholic fatty liver disease.
Keywords: Causal effects; Gut microbiota; Mendelian randomization; Nonalcoholic fatty liver disease.
Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Conflict of interest The authors have no relevant financial or non-financial interests to disclose.
Comment in
- A two-sample Mendelian randomization study to identity microbiome signatures in patients with Non-alcoholic fatty liver disease.
Forlano R, Sigon G. Forlano R, et al. Dig Liver Dis. 2023 Nov;55(11):1462-1463. doi: 10.1016/j.dld.2023.07.029. Epub 2023 Aug 1. Dig Liver Dis. 2023. PMID: 37537013 No abstract available.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical